沙眼衣原体热休克蛋白60和70在体外感染人子宫内膜上皮细胞系过程中的定位
Localization of Chlamydia trachomatis heat shock proteins 60 and 70 during infection of a human endometrial epithelial cell line in vitro.
作者信息
Raulston J E, Paul T R, Knight S T, Wyrick P B
机构信息
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599-7290, USA.
出版信息
Infect Immun. 1998 May;66(5):2323-9. doi: 10.1128/IAI.66.5.2323-2329.1998.
Abstract
Unlike chlamydial lipopolysaccharide, which is released from the developing inclusion to the surface of infected genital epithelial cells, both Chlamydia trachomatis heat shock protein (hsp) 60 and 70 antigens remained confined within the inclusion during the course of the chlamydial developmental cycle. Exposure of the infected cells to penicillin to induce a persistent infection or to a lipophilic microbicide did not potentiate secretion or exocytosis of the chlamydial hsp.
摘要
与从正在发育的包涵体释放到受感染的生殖上皮细胞表面的衣原体脂多糖不同，沙眼衣原体热休克蛋白（hsp）60和70抗原在衣原体发育周期过程中始终局限于包涵体内。用青霉素处理受感染细胞以诱导持续性感染或用亲脂性杀菌剂处理，均不会增强衣原体hsp的分泌或胞吐作用。
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