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Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host.粪肠球菌突变影响秀丽隐杆线虫模式宿主的毒力。

Infect Immun. 2007 May;75(5):2634-7. doi: 10.1128/IAI.01372-06. Epub 2007 Feb 16.

2

Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.粪肠球菌蛋白酶基因和群体感应位点fsr在秀丽隐杆线虫和小鼠中的毒力效应

Infect Immun. 2002 Oct;70(10):5647-50. doi: 10.1128/IAI.70.10.5647-5650.2002.

3

Implication of hypR in the virulence and oxidative stress response of Enterococcus faecalis.hypR在粪肠球菌毒力和氧化应激反应中的作用

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4

Importance of gls24 in virulence and stress response of Enterococcus faecalis and use of the Gls24 protein as a possible immunotherapy target.Gls24在粪肠球菌毒力和应激反应中的重要性以及将Gls24蛋白用作可能的免疫治疗靶点

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A genomic virulence reference map of Enterococcus faecalis reveals an important contribution of phage03-like elements in nosocomial genetic lineages to pathogenicity in a Caenorhabditis elegans infection model.粪肠球菌的基因组毒力参考图谱揭示了在秀丽隐杆线虫感染模型中，医院遗传谱系中类噬菌体03元件对致病性的重要贡献。

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Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.明胶酶、丝氨酸蛋白酶和fsr在粪肠球菌眼内炎发病机制中的作用。

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Vitamin B12 Deficiency Alters the Gut Microbiota in a Murine Model of Colitis.维生素B12缺乏改变结肠炎小鼠模型中的肠道微生物群。

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本文引用的文献

1

Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.通过转录分析比较OG1RF和同基因fsrB缺失突变体：粪肠球菌的Fsr系统不仅仅是明胶酶和丝氨酸蛋白酶的激活剂。

J Bacteriol. 2006 Apr;188(8):2875-84. doi: 10.1128/JB.188.8.2875-2884.2006.

2

Enterococcus faecalis mammalian virulence-related factors exhibit potent pathogenicity in the Arabidopsis thaliana plant model.粪肠球菌哺乳动物毒力相关因子在拟南芥植物模型中表现出强大的致病性。

Infect Immun. 2005 Jan;73(1):464-75. doi: 10.1128/IAI.73.1.464-475.2005.

3

Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns.粪肠球菌Tn917介导的基因破坏文库的构建有助于深入了解Tn917的插入模式。

J Bacteriol. 2004 Nov;186(21):7280-9. doi: 10.1128/JB.186.21.7280-7289.2004.

4

Involvement of Streptococcus gordonii beta-glucoside metabolism systems in adhesion, biofilm formation, and in vivo gene expression.戈登链球菌β-葡萄糖苷代谢系统在黏附、生物膜形成及体内基因表达中的作用。

J Bacteriol. 2004 Jul;186(13):4246-53. doi: 10.1128/JB.186.13.4246-4253.2004.

5

Starvation survival, growth and recovery of Enterococcus faecalis in human serum.粪肠球菌在人血清中的饥饿存活、生长及恢复情况

Oral Microbiol Immunol. 2003 Aug;18(4):234-9. doi: 10.1034/j.1399-302x.2003.00072.x.

6

Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.移动DNA在耐万古霉素粪肠球菌进化中的作用。

Science. 2003 Mar 28;299(5615):2071-4. doi: 10.1126/science.1080613.

7

Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica.通过对细胞内肠炎沙门氏菌进行基因表达谱分析来揭示巨噬细胞感染的生物学机制。

Mol Microbiol. 2003 Jan;47(1):103-18. doi: 10.1046/j.1365-2958.2003.03313.x.

8

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.粪肠球菌fsrB基因是fsr群体感应系统的关键组成部分，与兔眼内炎模型中的毒力相关。

Infect Immun. 2002 Aug;70(8):4678-81. doi: 10.1128/IAI.70.8.4678-4681.2002.

9

A simple model host for identifying Gram-positive virulence factors.一种用于鉴定革兰氏阳性菌毒力因子的简单模式宿主。

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10892-7. doi: 10.1073/pnas.191378698. Epub 2001 Sep 4.

10

Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence.粪肠球菌fsr基因对明胶酶和丝氨酸蛋白酶产生及毒力的影响。

Infect Immun. 2000 May;68(5):2579-86. doi: 10.1128/IAI.68.5.2579-2586.2000.

粪肠球菌突变影响秀丽隐杆线虫模式宿主的毒力。

Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host.

作者信息

Maadani Arash, Fox Kristina A, Mylonakis Elftherios, Garsin Danielle A

机构信息

Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, 6431 Fannin St./MSB 1.174, Houston, TX 77030, USA.

出版信息

Infect Immun. 2007 May;75(5):2634-7. doi: 10.1128/IAI.01372-06. Epub 2007 Feb 16.

DOI:10.1128/IAI.01372-06

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865755/

Abstract

Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.

摘要

筛选粪肠球菌转座子插入突变体，以检测其对模式宿主秀丽隐杆线虫的杀伤能力减弱情况。在杀伤能力减弱的突变体中被破坏的基因编码多种因子，包括转录调节因子、转运蛋白以及损伤控制和修复系统。所测试的九个突变体中有五个在小鼠腹膜炎模型中表现出杀伤能力减弱。