Nitschke Jonathan R
Department of Organic Chemistry, University of Geneva, 30 quai Ernest-Ansermet, 1211 Genève 4, Switzerland.
Acc Chem Res. 2007 Feb;40(2):103-12. doi: 10.1021/ar068185n.
Subcomponent self-assembly allows the construction of complex architectures from simple building blocks via formation of covalent bonds around metal templates. Since both covalent and coordinative bonds are formed reversibly, a wealth of rearrangement reactions is possible involving substitution at both intraligand (often C=N) and metal-ligand (N --> metal) bonds. If the possibilities latent within a set of subcomponents and metal ions are understood, one may also select specific structures from among dynamic libraries of products. The parallel preparation of structures from "nonorthogonal" mixtures of subcomponents is also possible, as is the direction of subcomponents to specific sites within product structures.
子组件自组装能够通过围绕金属模板形成共价键，从简单的构建单元构建复杂的结构。由于共价键和配位键都是可逆形成的，因此存在大量的重排反应，包括配体内（通常是C=N）和金属-配体（N→金属）键的取代反应。如果理解了一组子组件和金属离子中潜在的可能性，那么也可以从动态产物库中选择特定的结构。从子组件的“非正交”混合物中并行制备结构也是可能的，子组件导向产物结构内特定位点的情况同样如此。
