植入纳曲酮的患者可能会发生阿片类药物过量死亡。
Opioid overdose deaths can occur in patients with naltrexone implants.
作者信息
Gibson Amy E, Degenhardt Louisa J, Hall Wayne D
机构信息
National Drug and Alcohol Research Centre, University of New South Wales, Sydney.
出版信息
Med J Aust. 2007 Feb 5;186(3):152-3. doi: 10.5694/j.1326-5377.2007.tb01126.x.
From Australian coronial records, we identified five deaths involving implantable naltrexone between 2000 and 2004. One man died from acute narcotism with a naltrexone implant in place and a blood naltrexone level of 0.3 mg/L. A woman died of combined drug effect (including naltrexone) accompanied by severe pain from a naltrexone implant site. These cases indicate that patients can die from opioid overdose with a naltrexone implant and blood naltrexone levels higher than reported blockade levels.
从澳大利亚死因裁判记录中，我们识别出2000年至2004年间五起涉及植入式纳曲酮的死亡案例。一名男子在植入纳曲酮的情况下死于急性麻醉，血液中纳曲酮水平为0.3毫克/升。一名女子死于药物联合作用（包括纳曲酮），同时伴有纳曲酮植入部位的剧痛。这些案例表明，植入纳曲酮且血液中纳曲酮水平高于报告的阻滞水平时，患者可能死于阿片类药物过量。
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