Akinturk S, Eroglu A
Department of Anaesthesiology, Karadeniz Technical University, Trabzon, Turkey.
J Eur Acad Dermatol Venereol. 2007 Mar;21(3):380-3. doi: 10.1111/j.1468-3083.2006.01979.x.
Laser-assisted hair removal is a variably uncomfortable and painful procedure.
The aim of this study was to investigate the efficacy of piroxicam gel on pain control and subsequent inflammation in Nd:YAG 1064 nm laser hair removal in women volunteers.
Fifty women volunteers were enrolled in this prospective, randomised, placebo-controlled study over a 6-month period. Subjects were randomly assigned to receive piroxicam gel as Group P or saline as a control group. Topical analgesic and saline were applied to the treatment sites for 45 minutes. The pain scores (VAS) and side effects were recorded before the hair removal, during the hair removal, at the end of the hair removal, and after 1 hour, 2 hours and 24 hours after the hair removal.
Subject characteristics and treatment settings in Nd:YAG 1064 nm laser were similar in both groups. The pain scores (VAS) were significantly lower in the Group P than those of the control group during the hair removal (p < 0.001). Inflammatory side effects such as erythema, edema, and folliculitis, were more frequent in the control group than those of Group P during the procedure (p < 0.001).
This study showed that piroxicam gel provided adequate pain relief after Nd:YAG 1064 nm laser hair removal in women volunteers. Piroxicam gel was associated with lesser inflammatory side effects when compared to placebo because of its anti-inflammatory effect after the procedure.
激光辅助脱毛是一种程度不一的不适且疼痛的 procedure。
本研究的目的是调查吡罗昔康凝胶对女性志愿者在 Nd:YAG 1064 nm 激光脱毛中疼痛控制及后续炎症的疗效。
五十名女性志愿者参与了这项为期 6 个月的前瞻性、随机、安慰剂对照研究。受试者被随机分配接受吡罗昔康凝胶作为 P 组或生理盐水作为对照组。局部镇痛药和生理盐水在治疗部位涂抹 45 分钟。在脱毛前、脱毛期间、脱毛结束时以及脱毛后 1 小时、2 小时和 24 小时记录疼痛评分（视觉模拟评分法）和副作用。
两组在 Nd:YAG 1064 nm 激光的受试者特征和治疗设置相似。在脱毛期间，P 组的疼痛评分（视觉模拟评分法）显著低于对照组（p < 0.001）。在该过程中，对照组的炎症副作用如红斑、水肿和毛囊炎比 P 组更频繁（p < 0.001）。
本研究表明，吡罗昔康凝胶在女性志愿者 Nd:YAG 1064 nm 激光脱毛后提供了充分的疼痛缓解。由于其术后抗炎作用，与安慰剂相比，吡罗昔康凝胶的炎症副作用较小。
