Xiao Ming, Sun Xing-huai, Meng Fan-rong, Fang Zhao-bin, Qiu Si-yu, Guo Wen-yi, Qian Shao-hong, Wang Ju-ying
Shanghai Beizhan Hospital, Zhabei District, Shanghai 200070, China.
Zhonghua Yi Xue Za Zhi. 2011 Feb 22;91(7):441-4.
To analyze the discipline of intraocular pressure (IOP) variation, through circadian intraocular pressure monitoring in primary open-angle glaucoma (POAG) patients and normal controls, with a view to provide basis for individualized treatment of glaucoma.
Subjects were enrolled from the outpatients of Shanghai Beizhan Hospital and Eye and ENT Hospital of Fudan University, which were diagnosed as primary open angle glaucoma, from April 2006 to April 2009. Totally there were 102 cases of patients and 83 cases of normal volunteers. All the subjects accepted 24-hour IOP measurements using non-contact tonometer every two hours starting from 8:00 am. And the IOP between 00:00 to 06:00 am was measured in sitting position immediately after wake up.
The differences of peak IOP [(16.0 ± 2.7) mm Hg of right eye and (16.2 ± 2.7) mm Hg of left eye in normal group; (25.3 ± 5.6) mm Hg of right eye and (24.8 ± 5.1) mm Hg of left eye in POAG group], valley IOP (11.1 ± 2.5) mm Hg of right eye and (11.0 ± 2.3) mm Hg of left eye in normal group; (16.3 ± 3.7) mm Hg of right eye and (16.2 ± 3.3) mm Hg of left eye in POAG group, average IOP (13.4 ± 2.5) mm Hg of right eye and (13.4 ± 2.5) mm Hg of left eye in normal group; (19.9 ± 4.3) mm Hg of right eye and (19.8 ± 3.8) mm Hg of left eye in POAG group), and IOP fluctuations (5.0 ± 1.6) mm Hg of right eye and (5.2 ± 1.7) mm Hg of left eye in normal group; (9.1 ± 3.6) mm Hg of right eye and (8.6 ± 3.8) mm Hg of left eye in POAG group between two groups were all of statistically significance (P < 0.01). Notably, the peak IOP of 59.6% in normal control group and 73.5% in POAG group were outside working hours, especially in the time period from 00:00 to 06:00 am. The peak value of 50% in normal group and 64.7% in POAG group located between 00:00 to 06:00 in the morning.
By comparison and analysis, 24-hour intraocular pressure measurement could provide us pre-treatment basic state, so as to provide detailed information for individualized treatment. If possible, it is suggested that 24-hour IOP monitoring should be added as a routine examination of primary open angle glaucoma.
通过对原发性开角型青光眼（POAG）患者和正常对照者进行昼夜眼压监测，分析眼压（IOP）变化规律，为青光眼的个体化治疗提供依据。
选取2006年4月至2009年4月在上海北站医院和复旦大学附属眼耳鼻喉科医院门诊确诊为原发性开角型青光眼的患者102例及正常志愿者83例。所有受试者从上午8:00开始每两小时使用非接触眼压计进行一次24小时眼压测量。凌晨00:00至06:00的眼压在醒来后立即坐位测量。
两组间眼压峰值[正常组右眼（16.0±2.7）mmHg、左眼（16.2±2.7）mmHg；POAG组右眼（25.3±5.6）mmHg、左眼（24.8±5.1）mmHg]、眼压谷值[正常组右眼（11.1±2.5）mmHg、左眼（11.0±2.3）mmHg；POAG组右眼（16.3±3.7）mmHg、左眼（16.2±3.3）mmHg]、平均眼压[正常组右眼（13.4±2.5）mmHg、左眼（13.4±2.5）mmHg；POAG组右眼（19.9±4.3）mmHg、左眼（19.8±3.8）mmHg]及眼压波动[正常组右眼（5.0±1.6）mmHg、左眼（5.2±1.7）mmHg；POAG组右眼（9.1±3.6）mmHg、左眼（8.6±3.8）mmHg]差异均有统计学意义（P<0.01）。值得注意的是，正常对照组59.6%的眼压峰值和POAG组73.5%的眼压峰值出现在工作时间之外，尤其是在凌晨00:00至06:00时间段。正常组50%的峰值和POAG组64.7%的峰值出现在凌晨00:00至06:00之间。
通过对比分析，24小时眼压测量可提供治疗前的基础状态，为个体化治疗提供详细信息。如有可能，建议将24小时眼压监测作为原发性开角型青光眼的常规检查项目。
