Chiseliţă D, Moţoc Irina, Danielescu C
Clinica I Oftalmologie, Sp. Sf. Spiridon, Iaşi.
Oftalmologia. 2008;52(3):102-9.
To study the concordance of nictemeral IOP variations between fellow eyes in patients with treated and untreated OHT/POAG versus non-glaucoma patients. Also, we evaluate the symmetry or asymmetry level of mean, peak and IOP fluctuations between fellow eyes in glaucoma patients compared with normal controls.
Cross-sectional study.
Applanation IOP and blood pressure were measured every 2 hours by one observer for 24 hours in 124 patients. The patients were classified: group 1--36 non-glaucoma patients (control group), group 2--32 patients with OHT and POAG without treatment, group 3--43 patients with OHT and POAG with a satisfactory diurnal therapeutic control of IOP (daytime IOP>21 mmHg) and group 4--13 patients with POAG with unsatisfactory control of IOP under maximal tolerated medication (daytime IOP>21 mmHg).
The nictemeral curves of fellow eyes exhibited parallel profiles; according to the paired t-test there were no significant differences between fellow eyes throughout all measurement intervals. There is a high correlation of 24 h IOP between fellow eyes in all our study groups (r=0.8632, p<0.0001). There were no significant differences between fellow eyes in moment or value of peak IOP (paired t-test p=0.53). Comparing the mean absolute differences in IOP between fellow eyes throughout all 12 measurement points, the smallest differences between fellow eyes were found in groups 1 and 3 (0.85 mmHg, respectively 0.90 mmHg, p=0.47). The differences between fellow eyes were significantly greater in groups 2 and 4 (1.28 mmHg, respectively 2.6 mmHg, p<0.0001). The greatest probability of IOP differences to be in +/- 3 mmHg interval was found in normal patients (97.91%) and in patients with therapeutic control of IOP (97.26%). The greatest asymmetry of IOP was found in the group with therapeutically uncontrolled IOP (over 1/5 measurements were outside the +/- 3 mmHg interval).
The nictemeral variation of IOP in glaucoma patients were largely concordant between fellow eyes and the 24-hour IOP curves of fellow eyes exhibited parallel profiles. There were no significant differences between fellow eyes in mean, peak and IOP fluctuations. The asymmetry over +/- 3 mmHg between fellow eyes varied from 2.09% in normals to 20.53% in patients with therapeutically uncontrolled IOP.
研究接受治疗和未接受治疗的高眼压症/原发性开角型青光眼（OHT/POAG）患者与非青光眼患者患眼间昼夜眼压（IOP）变化的一致性。此外，我们评估了青光眼患者患眼与正常对照者患眼之间平均眼压、峰值眼压及眼压波动的对称或不对称水平。
横断面研究。
由一名观察者每2小时测量124例患者的眼压及血压，持续24小时。患者分为四组：第1组为36例非青光眼患者（对照组）；第2组为32例未经治疗的OHT/POAG患者；第3组为43例OHT/POAG患者，其眼压在日间得到满意的治疗控制（日间眼压>21 mmHg）；第4组为13例POAG患者，其眼压在最大耐受药物治疗下控制不佳（日间眼压>21 mmHg）。
患眼的昼夜眼压曲线呈现平行形态；根据配对t检验，在所有测量时段内，患眼之间均无显著差异。在我们所有研究组中，患眼的24小时眼压具有高度相关性（r = 0.8632，p < 0.0001）。患眼在眼压峰值时刻或数值方面无显著差异（配对t检验，p = 0.53）。比较所有12个测量点患眼之间眼压的平均绝对差值，第1组和第3组患眼之间的差值最小（分别为0.85 mmHg和0.90 mmHg，p = 0.47）。第2组和第4组患眼之间的差值显著更大（分别为1.28 mmHg和2.6 mmHg，p < 0.0001）。眼压差值在±3 mmHg区间内的最大概率出现在正常患者（97.91%）和眼压得到治疗控制的患者中（97.26%）。眼压不对称性最大的情况出现在眼压治疗控制不佳的组中（超过1/5的测量值超出±3 mmHg区间）。
青光眼患者患眼间的昼夜眼压变化在很大程度上是一致的，患眼的24小时眼压曲线呈现平行形态。患眼在平均眼压、峰值眼压及眼压波动方面无显著差异。患眼之间±3 mmHg以上的不对称性在正常人群中为2.09%，在眼压治疗控制不佳的患者中为20.53%。
