• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome.日本史蒂文斯-约翰逊综合征患者的Toll样受体3基因多态性
Br J Ophthalmol. 2007 Jul;91(7):962-5. doi: 10.1136/bjo.2006.113449. Epub 2007 Feb 21.
2
Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications.白细胞介素-13/白细胞介素-4受体信号通路相关基因多态性与伴眼表并发症的史蒂文斯-约翰逊综合征的关联
Invest Ophthalmol Vis Sci. 2008 May;49(5):1809-13. doi: 10.1167/iovs.07-1401. Epub 2008 Feb 8.
3
Ocular surface inflammation mediated by innate immunity.由先天免疫介导的眼表面炎症。
Eye Contact Lens. 2010 Sep;36(5):269-81. doi: 10.1097/ICL.0b013e3181ee8971.
4
Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome.Fas配体基因多态性与史蒂文斯-约翰逊综合征的关联
Br J Ophthalmol. 2008 Jul;92(7):989-91. doi: 10.1136/bjo.2007.136796.
5
HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications.HLA-A*0206 与 TLR3 多态性在史蒂文斯-约翰逊综合征伴严重眼表并发症中发挥了超过相加的作用。
PLoS One. 2012;7(8):e43650. doi: 10.1371/journal.pone.0043650. Epub 2012 Aug 17.
6
Specific association of the rs6500265 and rs9933632 single-nucleotide polymorphisms in Japanese patients with antipyretic analgesic-related Stevens-Johnson syndrome and toxic epidermal necrolysis with severe ocular involvements.日本患者中，rs6500265和rs9933632单核苷酸多态性与解热镇痛相关的史蒂文斯-约翰逊综合征及伴有严重眼部受累的中毒性表皮坏死松解症的特定关联。
Pharmacogenet Genomics. 2018 Mar;28(3):95-98. doi: 10.1097/FPC.0000000000000324.
7
Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.史蒂文斯-约翰逊综合征伴有严重眼部并发症的详细调查结果。
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES183-DES191. doi: 10.1167/iovs.17-23537.
8
Genetic association of IFN-γ +874T/A polymorphism in Mexican patients with drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.IFN-γ +874T/A 多态性与墨西哥药物诱导的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症患者的遗传相关性。
Arch Dermatol Res. 2013 May;305(4):353-7. doi: 10.1007/s00403-012-1305-6. Epub 2012 Dec 8.
9
Epistatic interactions associated with Stevens-Johnson syndrome.与史蒂文斯-约翰逊综合征相关的上位性相互作用。
Cornea. 2012 Nov;31 Suppl 1:S57-62. doi: 10.1097/ICO.0b013e31826a7f41.
10
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.伴有严重眼表并发症的史蒂文斯-约翰逊综合征的遗传易感性。
Cornea. 2015 Nov;34 Suppl 11:S158-65. doi: 10.1097/ICO.0000000000000605.

引用本文的文献

1
Regulation of innate immune response by miRNAs up-regulated in Stevens-Johnson syndrome with severe ocular complications.在伴有严重眼部并发症的史蒂文斯-约翰逊综合征中上调的微小RNA对固有免疫反应的调节
Sci Rep. 2025 Jan 6;15(1):893. doi: 10.1038/s41598-025-85528-8.
2
Severe ocular complications of SJS/TEN and associations among pre-onset, acute, and chronic factors: a report from the international ophthalmology collaborative group.史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的严重眼部并发症及发病前、急性期和慢性期因素之间的关联：国际眼科协作组报告
Front Med (Lausanne). 2023 Jun 22;10:1189140. doi: 10.3389/fmed.2023.1189140. eCollection 2023.
3
Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells.TLR3 和 IPS-1 信号对小鼠角膜上皮细胞基因调控的差异。
Sci Rep. 2023 May 16;13(1):7925. doi: 10.1038/s41598-023-35144-1.
4
Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC.感冒药相关的重症多形红斑/中毒性表皮坏死松解症伴标准治疗的易感性基因与人类白细胞抗原
Front Genet. 2022 Jul 11;13:912478. doi: 10.3389/fgene.2022.912478. eCollection 2022.
5
The Immunogenetics of Cutaneous Drug Reactions.皮肤药物反应的免疫遗传学。
Adv Exp Med Biol. 2022;1367:411-431. doi: 10.1007/978-3-030-92616-8_17.
6
Findings by an International Collaboration on SJS/TEN With Severe Ocular Complications.一项关于伴有严重眼部并发症的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的国际合作研究结果。
Front Med (Lausanne). 2021 Dec 1;8:649661. doi: 10.3389/fmed.2021.649661. eCollection 2021.
7
Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications.伴有严重眼部并发症的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的发病机制。
Front Med (Lausanne). 2021 Nov 17;8:651247. doi: 10.3389/fmed.2021.651247. eCollection 2021.
8
Categorization of the Ocular Microbiome in Japanese Stevens-Johnson Syndrome Patients With Severe Ocular Complications.日本史蒂文斯-约翰逊综合征患者严重眼部并发症的眼微生物组分类。
Front Cell Infect Microbiol. 2021 Nov 19;11:741654. doi: 10.3389/fcimb.2021.741654. eCollection 2021.
9
Toxic Epidermal Necrolysis Secondary to Metronidazole.甲硝唑继发中毒性表皮坏死松解症
Cureus. 2021 Aug 11;13(8):e17101. doi: 10.7759/cureus.17101. eCollection 2021 Aug.
10
Toll-Like Receptors in Dermatology, Venereology, and Leprosy.皮肤病学、性病学和麻风病中的Toll样受体
Indian J Dermatol. 2021 Mar-Apr;66(2):223. doi: 10.4103/ijd.IJD_486_17.

本文引用的文献

1
New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome.史蒂文斯-约翰逊综合征患者慢性眼部表现评估的新分级系统。
Ophthalmology. 2007 Jul;114(7):1294-302. doi: 10.1016/j.ophtha.2006.10.029. Epub 2007 May 1.
2
Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.在日本人中，HLA - A*0206与史蒂文斯 - 约翰逊综合征之间存在强关联。
Am J Ophthalmol. 2007 Feb;143(2):367-8. doi: 10.1016/j.ajo.2006.09.029. Epub 2006 Oct 25.
3
Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells.Toll样受体3由人支气管上皮细胞的鼻病毒感染诱导产生，并介导针对该感染的抗病毒活性。
J Virol. 2005 Oct;79(19):12273-9. doi: 10.1128/JVI.79.19.12273-12279.2005.
4
Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes.南非1型糖尿病黑人中Toll样受体3基因多态性
Tissue Antigens. 2005 Aug;66(2):125-30. doi: 10.1111/j.1399-0039.2005.00454.x.
5
Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.聚肌胞苷酸（polyI:C）在人角膜上皮细胞中激活Toll样受体3（TLR3）以诱导炎性细胞因子。
Biochem Biophys Res Commun. 2005 May 27;331(1):285-94. doi: 10.1016/j.bbrc.2005.02.196.
6
Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice.IκBζ基因敲除小鼠的自发性眼表炎症和杯状细胞消失
Invest Ophthalmol Vis Sci. 2005 Feb;46(2):579-88. doi: 10.1167/iovs.04-1055.
7
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.细胞内表达的Toll样受体2（TLR2）和Toll样受体4（TLR4）对眼黏膜上皮免疫沉默环境的作用。
J Immunol. 2004 Sep 1;173(5):3337-47. doi: 10.4049/jimmunol.173.5.3337.
8
Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis.炎症性肠病中脂多糖信号复合物的多态性：Toll样受体4基因中的突变与溃疡性结肠炎的关联。
Clin Immunol. 2004 Jul;112(1):85-91. doi: 10.1016/j.clim.2004.03.002.
9
Medical genetics: a marker for Stevens-Johnson syndrome.医学遗传学：史蒂文斯-约翰逊综合征的一个标志物。
Nature. 2004 Apr 1;428(6982):486. doi: 10.1038/428486a.
10
Toll-like receptor 2 as a major gene for asthma in children of European farmers.Toll样受体2是欧洲农民子女哮喘的主要基因。
J Allergy Clin Immunol. 2004 Mar;113(3):482-8. doi: 10.1016/j.jaci.2003.12.374.

日本史蒂文斯-约翰逊综合征患者的Toll样受体3基因多态性

Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome.

作者信息

Ueta Mayumi, Sotozono Chie, Inatomi Tsutomu, Kojima Kentaro, Tashiro Kei, Hamuro Junji, Kinoshita Shigeru

机构信息

Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Hirokoji, Kawaramachi, Kamigyoku, Kyoto 602-0841, Japan.

出版信息

Br J Ophthalmol. 2007 Jul;91(7):962-5. doi: 10.1136/bjo.2006.113449. Epub 2007 Feb 21.

DOI:10.1136/bjo.2006.113449
PMID:17314152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2266833/
Abstract

BACKGROUND AND AIM

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. Given the association between the onset of SJS/TEN and infections, the possibility that there is an association between SJS/TEN and a disordered innate immune response was considered. The first line of defence against infection is comprised of evolutionarily conserved sets of molecules, the Toll-like receptors (TLRs). TLR3 recognises double-stranded RNA associated with viral infections.

METHODS

The Japanese single-nucleotide-polymorphism (JSNP) database reports 7 polymorphisms consisting of 7 SNPs in the human TLR3 gene; 3 of the 7 SNPs are coded in exon regions, (ie, 293248A/G, 293391A/G and 299698T/G), and the other 4 are coded in intron regions, (ie, 294440G/C, 294732C/T, 208036T/C and 298054C/T). These 7 SNPs were analysed in 57 Japanese patients with SJS/TEN with ocular surface complications and in 160 Japanese healthy controls.

RESULTS

SNP 299698T/G and the genotype patterns of 293248A/A and 299698T/T were strongly associated with SJS/TEN.

CONCLUSION

The results suggest that polymorphisms in the TLR3 gene could be associated with SJS/TEN in the Japanese population.

摘要

背景与目的

史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是由感染因子和/或诱发药物引起的急性起病的黏膜皮肤疾病。鉴于SJS/TEN的发病与感染之间的关联，人们考虑SJS/TEN与先天性免疫反应紊乱之间存在关联的可能性。抵御感染的第一道防线由进化上保守的分子组即Toll样受体（TLR）组成。TLR3识别与病毒感染相关的双链RNA。

方法

日本单核苷酸多态性（JSNP）数据库报告了人类TLR3基因中由7个单核苷酸多态性（SNP）组成的7种多态性；7个SNP中的3个在外显子区域编码（即293248A/G、293391A/G和299698T/G），另外4个在内含子区域编码（即294440G/C、294732C/T、208036T/C和298054C/T）。对57例患有眼表并发症的日本SJS/TEN患者和160例日本健康对照者分析了这7个SNP。

结果

SNP 299698T/G以及293248A/A和299698T/T的基因型模式与SJS/TEN密切相关。

结论

结果表明，TLR3基因多态性可能与日本人群的SJS/TEN有关。