Kolf Catherine M, Cho Elizabeth, Tuan Rocky S
Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Arthritis Res Ther. 2007;9(1):204. doi: 10.1186/ar2116.
Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.
在理解成体间充质干细胞的细胞和分子信号通路以及全局转录调节因子方面的最新进展，为其生物学特性及潜在临床应用，尤其是组织修复和再生，提供了新的见解。本综述聚焦于这些进展，特别是在间充质干细胞自我更新和谱系特异性分化调控的背景下。此外，我们还综述了关于干细胞微环境概念及其与成体间充质干细胞相关性的最新研究。
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