Tripathy Manas K, Deswal Renu, Sopory Sudhir K
1International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India; 2Department of Botany, University of Delhi, Delhi 110007, India.
Curr Genomics. 2021 Jan;22(1):26-40. doi: 10.2174/1389202922666210114102743.
Endosomal trafficking plays an integral role in various eukaryotic cellular activities and is vital for higher-order functions in multicellular organisms. RAB GTPases are important proteins that influence various aspects of membrane traffic, which consequently influence many cellular functions and responses. Compared to yeast and mammals, plants have evolved a unique set of plant-specific RABs that play a significant role in their development. RABs form the largest family of small guanosine triphosphate (GTP)-binding proteins, and are divided into eight sub-families named RAB1, RAB2, RAB5, RAB6, RAB7, RAB8, RAB11 and RAB18. Recent studies on different species suggest that RAB proteins play crucial roles in intracellular trafficking and cytokinesis, in autophagy, plant microbe interactions and in biotic and abiotic stress responses. This review recaptures and summarizes the roles of RABs in plant cell functions and in enhancing plant survival under stress conditions.
内体运输在各种真核细胞活动中起着不可或缺的作用，对于多细胞生物的高阶功能至关重要。RAB GTP酶是影响膜运输各个方面的重要蛋白质，进而影响许多细胞功能和反应。与酵母和哺乳动物相比，植物进化出了一组独特的植物特异性RAB，它们在植物发育中发挥着重要作用。RAB构成了小GTP结合蛋白的最大家族，分为八个亚家族，分别命名为RAB1、RAB2、RAB5、RAB6、RAB7、RAB8、RAB11和RAB18。最近对不同物种的研究表明，RAB蛋白在细胞内运输、胞质分裂、自噬、植物与微生物相互作用以及生物和非生物胁迫反应中发挥着关键作用。本综述回顾并总结了RAB在植物细胞功能以及增强植物在胁迫条件下生存能力方面的作用。
