α-生育酚和γ-生育酚的抗炎特性
Anti-inflammatory properties of alpha- and gamma-tocopherol.
作者信息
Reiter Elke, Jiang Qing, Christen Stephan
机构信息
Institute for Infectious Diseases, University of Berne, Friedbühlstrasse 51, CH-3010 Berne, Switzerland.
出版信息
Mol Aspects Med. 2007 Oct-Dec;28(5-6):668-91. doi: 10.1016/j.mam.2007.01.003. Epub 2007 Jan 11.
Abstract
Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin E, alpha-tocopherol (alphaT) and gamma-tocopherol (gammaT), and discuss the potential molecular mechanisms involved in these effects. While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gammaT-enriched) tocopherols seems to be more potent than supplementation with alphaT alone. This may explain the mostly negative outcomes of the recent large-scale interventional chronic disease prevention trials with alphaT only and thus warrants further investigation.
摘要
天然维生素E由四种不同的生育酚和四种不同的生育三烯酚同系物（α、β、γ、δ）组成，它们都具有抗氧化活性。然而，最近的数据表明，不同的维生素E同系物还具有与其抗氧化活性无关的生物活性。在这篇综述中，我们讨论了维生素E的两种主要形式，α-生育酚（αT）和γ-生育酚（γT）的抗炎特性，并探讨了这些作用所涉及的潜在分子机制。虽然两种生育酚在体外和体内均表现出抗炎活性，但补充混合（富含γT）生育酚似乎比单独补充αT更有效。这可能解释了最近仅使用αT的大规模干预性慢性病预防试验大多得出负面结果的原因，因此值得进一步研究。
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