Lotito A P N, Silva C A A, Mello S B V
Department of Paediatrics, University of Sao Paulo, Brazil.
Autoimmun Rev. 2007 Mar;6(4):253-6. doi: 10.1016/j.autrev.2006.08.010. Epub 2006 Aug 28.
Interleukin-18 is a cytokine member of the IL-1 super family that seems to exert powerful Th1-promoting activities in synergy with IL-12. Here we describe the participation of IL-18 in inflammatory joint diseases, in particular rheumatoid arthritis, adult onset Still's disease and juvenile idiopathic arthritis. The emphasis of this study was to summarize in vivo and in vitro studies that focused the action of this pro-inflammatory cytokine on the arthritic process as well as its role in the complex network of chemical mediators involved.
白细胞介素-18是白细胞介素-1超家族的一种细胞因子成员，它似乎与白细胞介素-12协同发挥强大的促进Th1细胞的活性。在此，我们描述白细胞介素-18在炎性关节疾病中的参与情况，特别是类风湿关节炎、成人斯蒂尔病和幼年特发性关节炎。本研究的重点是总结体内和体外研究，这些研究聚焦于这种促炎细胞因子在关节炎进程中的作用及其在相关化学介质复杂网络中的作用。
