α6β4整合素参与调节乳腺癌进展的机制。
Involvement of alpha6beta4 integrin in the mechanisms that regulate breast cancer progression.
作者信息
Bon Giulia, Folgiero Valentina, Di Carlo Selene, Sacchi Ada, Falcioni Rita
机构信息
Regina Elena Cancer Institute, Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro, 00158 Rome, Italy.
出版信息
Breast Cancer Res. 2007;9(1):203. doi: 10.1186/bcr1651.
Abstract
Integrin alpha6beta4 is mostly expressed in epithelial tissues and endothelial and Schwann cells. Expression of alpha6beta4 is increased in many epithelial tumours, implicating its involvement in tumour malignancy. Moreover, this integrin activates several key signalling molecules in carcinoma cells, but its ability to activate the phosphatidylinositol 3-kinase/Akt pathway is among the mechanisms by which alpha6beta4 integrin regulates tumour behaviour. In this review we discuss the biological and clinical features of alpha6beta4 integrin that allow it to promote tumour survival and progression of mammary tumours.
摘要
整合素α6β4主要表达于上皮组织、内皮细胞和雪旺细胞。α6β4在许多上皮肿瘤中的表达增加，这表明其参与肿瘤的恶性发展。此外，这种整合素可激活癌细胞中的几种关键信号分子，但其激活磷脂酰肌醇3-激酶/蛋白激酶B途径的能力是α6β4整合素调节肿瘤行为的机制之一。在本综述中，我们讨论了α6β4整合素的生物学和临床特征，这些特征使其能够促进乳腺肿瘤的存活和进展。
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