Butterfield J H, Leiferman K M, Abrams J, Silver J E, Bower J, Gonchoroff N, Gleich G J
Division of Allergic Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Blood. 1992 Feb 1;79(3):688-92.
The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the percentage of activated T cells in the peripheral blood of a new patient before and during an attack. In the patient presented, IL-5 levels peaked several days before maximal eosinophilia and then declined. This patient's lymphocytes showed an increased percentage, 28% (normal 2% to 3%), of activated T cells staining for both CD3 and HLA-DR 10 days before maximal eosinophilia, but no increase at the time of peak eosinophilia. In serum from three previously reported cases, elevated serum IL-5 levels were found during attacks. After glucocorticoid administration, IL-5 levels became undetectable in three of the four patients. Production of IL-5 is likely an important determinant of the pathophysiology of this syndrome.
发作性血管性水肿伴嗜酸性粒细胞增多综合征的特征为周期性水肿、显著的外周血嗜酸性粒细胞增多以及真皮内嗜酸性粒细胞脱颗粒。我们采用一种灵敏的免疫酶法，检测了4例该综合征患者的血清白细胞介素（IL）-5水平。我们还测定了1例新患者在发作前及发作期间外周血中活化T细胞的百分比。在所报道的患者中，IL-5水平在嗜酸性粒细胞增多达到峰值前数天达到高峰，然后下降。该患者的淋巴细胞在嗜酸性粒细胞增多达到峰值前10天，CD3和HLA-DR双阳性的活化T细胞百分比增加至28%（正常为2%至3%），但在嗜酸性粒细胞增多达到峰值时未增加。在先前报道的3例病例的血清中，发作期间发现血清IL-5水平升高。4例患者中有3例在给予糖皮质激素后，IL-5水平变得无法检测到。IL-5的产生可能是该综合征病理生理学的一个重要决定因素。
