Re Richard N, Cook Julia L
Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, United States.
Med Hypotheses. 2007;69(2):414-21. doi: 10.1016/j.mehy.2006.10.065. Epub 2007 Feb 22.
Angiogenesis, in most cases, is a requirement for tumor growth beyond a diameter of a few millimeters and is, therefore, a major target for cancer therapy. The intracellular actions of certain extracellular signaling proteins (intracrines) have been reported, and it is clear that intracrines such as vascular endothelial growth factor, basic fibroblast growth factor, angiogenin, angiotensin, and endothelin, among others, are involved in angiogenesis. We have proposed that intracrine networks play an important role in angiogenesis, and have suggested that very similar intracrine networks exist in some tumor cells. These notions have implications for the development of anti-angiogenesis therapies because they suggest that the inhibition of intracellular intracrine trafficking pathways may be an effective therapeutic target. Here the participation and regulation of intracrines in angiogenesis is explored, as are the actions of various anti-angiogenic factors.
在大多数情况下，血管生成是肿瘤生长超过几毫米直径所必需的，因此是癌症治疗的主要靶点。已经报道了某些细胞外信号蛋白（内分泌素）的细胞内作用，并且很明显，诸如血管内皮生长因子、碱性成纤维细胞生长因子、血管生成素、血管紧张素和内皮素等内分泌素参与了血管生成。我们提出内分泌素网络在血管生成中起重要作用，并表明在一些肿瘤细胞中存在非常相似的内分泌素网络。这些观点对抗血管生成疗法的发展具有启示意义，因为它们表明抑制细胞内内分泌素运输途径可能是一个有效的治疗靶点。本文探讨了内分泌素在血管生成中的参与和调节，以及各种抗血管生成因子的作用。
