脑微生态：成年哺乳动物脑中的神经干细胞龛
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain.
作者信息
Riquelme Patricio A, Drapeau Elodie, Doetsch Fiona
机构信息
Center for Neurobiology and Behavior, Columbia University, 630 West 168th Street, New York City, NY 10032, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):123-37. doi: 10.1098/rstb.2006.2016.
Abstract
Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are neural stem cells, capable of self-renewing and generating neurons and glia. Cues within the niche, from cell-cell interactions to diffusible factors, are spatially and temporally coordinated to regulate proliferation and neurogenesis, ultimately affecting stem cell fate choices. Here, we review the components of adult neural stem cell niches and how they act to regulate neurogenesis in these regions.
摘要
神经发生在成年哺乳动物大脑的两个生发区域持续存在，即侧脑室的室下区和海马结构的颗粒下区。在这两个神经发生微环境中，特殊的星形胶质细胞是神经干细胞，能够自我更新并产生神经元和神经胶质细胞。微环境中的信号，从细胞间相互作用到可扩散因子，在空间和时间上相互协调，以调节增殖和神经发生，最终影响干细胞的命运选择。在这里，我们综述成年神经干细胞微环境的组成部分以及它们如何在这些区域调节神经发生。
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