Mitchell N, Lee E R, Shepard N
Division of Orthopaedics, McGill University Shriners Hospital for Crippled Children, Montreal, Quebec, Canada.
J Bone Joint Surg Br. 1992 Jan;74(1):33-8. doi: 10.1302/0301-620X.74B1.1732261.
We studied the early cartilage changes in osteoarthritis, examining the most normal appearing articular cartilage from the hips of 17 patients. Normal appearing cartilage from five patients treated for fractures was used as control material. Two different types of clone were found. The first had increased staining for proteoglycan and was thought to have been engaged in the synthesis of matrix. The other type was associated with a severe deficiency of proteoglycan, matrix streaks and evidence of degradation and phagocytosis of matrix components. Immunohistochemistry demonstrated large amounts of chondroitin 4 and 6 sulphate about the synthetic-type clones, and little or no reactivity about the degenerative clones which lay more superficially and were associated with matrix destruction. Clones appeared to be engaged in either matrix synthesis or its destruction. The disease process of osteoarthritis appeared to begin at the surface of the articular cartilage.
我们研究了骨关节炎早期软骨的变化，检查了17例患者髋关节中外观最正常的关节软骨。将5例因骨折接受治疗患者的外观正常软骨用作对照材料。发现了两种不同类型的克隆体。第一种蛋白聚糖染色增加，被认为参与了基质的合成。另一种类型与蛋白聚糖严重缺乏、基质条纹以及基质成分降解和吞噬的证据有关。免疫组织化学显示，合成型克隆体周围有大量硫酸软骨素4和6，而位于更表层且与基质破坏相关的退化型克隆体几乎没有反应或没有反应。克隆体似乎参与了基质合成或其破坏过程。骨关节炎的疾病进程似乎始于关节软骨表面。
