Booij Linda, Van der Does A J Willem
Department of Psychology, Leiden University, Leiden, The Netherlands.
J Abnorm Psychol. 2007 Feb;116(1):86-94. doi: 10.1037/0021-843X.116.1.86.
Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed patients participated in 2 ATD sessions in a double-blind crossover design. CR, assessed prior to the ATD sessions, predicted depressive response to high-dose ATD. CR also diminished the effects of 2 known predictors of ATD response: gender and residual symptoms. Neuroticism and behavioral inhibition were unrelated to ATD response. CR is associated with an increased sensitivity to reductions of serotonin concentrations. These findings present a small step toward unifying cognitive and neurobiological theories of depression.
认知反应性（CR）是抑郁症的一种心理易感性标志物，而急性色氨酸耗竭（ATD；一种血清素激发程序）反应则是一种生物学易感性标志物。本研究的目的是调查这些标志物之间的关系。39名缓解期抑郁症患者以双盲交叉设计参加了2次ATD试验。在ATD试验之前评估的CR预测了对高剂量ATD的抑郁反应。CR还减弱了2个已知的ATD反应预测因素的作用：性别和残留症状。神经质和行为抑制与ATD反应无关。CR与血清素浓度降低的敏感性增加有关。这些发现朝着统一抑郁症的认知和神经生物学理论迈出了一小步。
