Burns Ted M, Schaublin Gregory A, Dyck P James B
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Neurol Clin. 2007 Feb;25(1):89-113. doi: 10.1016/j.ncl.2006.11.002.
The classification of vasculitis and the clinical features of vasculitic neuropathy are reviewed. Vasculitic neuropathy usually presents with painful mononeuropathies or an asymmetric polyneuropathy of acute or subacute onset. Neurologists should categorize vasculitic neuropathy in terms of clinical features (eg, systemic or non systemic) and in terms of histopathology (eg, nerve large arteriole vasculitis or nerve microvasculitis). Systemic vasculitis should be classified further into one of the primary and secondary forms. Steroids and cytotoxic agents have been the mainstay of therapy for most forms of vasculitic neuropathy. Dosing, potential side effects, and management recommendations of conventional therapies are provided.
本文综述了血管炎的分类以及血管炎性神经病的临床特征。血管炎性神经病通常表现为疼痛性单神经病或急性或亚急性起病的不对称性多发性神经病。神经科医生应根据临床特征（如全身性或非全身性）和组织病理学（如神经大动脉血管炎或神经微血管炎）对血管炎性神经病进行分类。全身性血管炎应进一步分为原发性和继发性形式之一。类固醇和细胞毒性药物一直是大多数形式的血管炎性神经病的主要治疗方法。文中提供了传统疗法的给药剂量、潜在副作用及管理建议。
