Brown David W, Giles Wayne H, Greenlund Kurt J
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Am J Hypertens. 2007 Mar;20(3):338-41. doi: 10.1016/j.amjhyper.2006.08.004.
Recent studies have suggested that systolic blood pressure (BP) is a better predictor of stroke than diastolic BP in apparently healthy white men. Whether these relationships are similar for women and African Americans remains unclear.
We used data from 6667 (3205 men; 3462 women) adults from the Second National Health and Nutrition Examination Survey Mortality Study to examine whether the relative risk of fatal stroke was associated with a 10 mm Hg increase in BP parameters (systolic BP, diastolic BP, pulse pressure, and mean arterial pressure).
During a median of nearly 15 years of follow-up, 113 fatal strokes (62 men; 51 women) occurred. Systolic BP was associated with an increased risk of fatal stroke for men (relative risk [RR] = 1.19), women (RR = 1.15), whites (RR = 1.17), and African Americans (RR = 1.28) after multivariable adjustment (all, P </= .05). Results for other BP parameters were not consistent; simultaneous consideration of two parameters did not improve prediction of fatal stroke over systolic BP alone.
Our results agree with previous studies that indicate systolic BP is an important predictor of stroke risk for all groups within the population and provide further evidence of the need to control systolic BP in the population.
最近的研究表明，在表面健康的白人男性中，收缩压（BP）比舒张压更能预测中风。这些关系在女性和非裔美国人中是否相似仍不清楚。
我们使用了来自第二次全国健康与营养检查调查死亡率研究的6667名成年人（3205名男性；3462名女性）的数据，以检查血压参数（收缩压、舒张压、脉压和平均动脉压）升高10毫米汞柱时，致命性中风的相对风险是否与之相关。
在近15年的中位随访期内，发生了113例致命性中风（62名男性；51名女性）。多变量调整后，收缩压与男性（相对风险[RR]=1.19）、女性（RR=1.15）、白人（RR=1.17）和非裔美国人（RR=1.28）致命性中风风险增加相关（所有P≤0.05）。其他血压参数的结果不一致；同时考虑两个参数并不能比单独考虑收缩压更好地预测致命性中风。
我们的结果与之前的研究一致，表明收缩压是人群中所有群体中风风险的重要预测指标，并进一步证明了在人群中控制收缩压的必要性。
