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基于纳米技术的低传能线密度多微束阵列单细胞辐照系统的开发。

Development of a nanotechnology based low-LET multi-microbeam array single cell irradiation system.

作者信息

Chang S, Zhang J, Bordelon D, Schreiber E, Cox A, Zhou O

机构信息

Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Radiat Prot Dosimetry. 2006;122(1-4):323-6. doi: 10.1093/rpd/ncl508. Epub 2007 Feb 26.

Abstract

A novel single cell irradiation system using carbon nanotube (CNT) based field emission technology is proposed. The system can produce electron microbeam at a large range of pulsation frequencies and dose rates with energy between 20 and 60 keV. Different from any existing single beam microbeam device, the CNT-based system can have 10,000 microbeam pixels, each is approximately 10 microm in size and individually controlled. Microscope imaging will be used for targeting cell(s) and the coordinate(s) identification. A single cell or large number of individually selected cells can be simultaneously irradiated under real time microscope observation. This poster reports our preliminary results in the initial stage of the CNT multipixel microbeam array development-prototype single pixel CNT microbeam device development.

摘要

提出了一种使用基于碳纳米管(CNT)场发射技术的新型单细胞辐照系统。该系统能够在20至60keV的能量范围内,以大范围的脉动频率和剂量率产生电子微束。与任何现有的单束微束装置不同,基于碳纳米管的系统可以有10000个微束像素,每个像素大小约为10微米且可单独控制。显微镜成像将用于靶向细胞和坐标识别。在实时显微镜观察下,可以同时对单个细胞或大量单独选择的细胞进行辐照。本海报报告了我们在碳纳米管多像素微束阵列开发的初始阶段——原型单像素碳纳米管微束装置开发中的初步结果。

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