慢性感染期间人类免疫缺陷病毒1型env V1/V2和V4/V5高变区的独立进化
Independent evolution of human immunodeficiency virus type 1 env V1/V2 and V4/V5 hypervariable regions during chronic infection.
作者信息
Harrington Patrick R, Nelson Julie A E, Kitrinos Kathryn M, Swanstrom Ronald
机构信息
University of North Carolina at Chapel Hill, 22-062 Lineberger Cancer Center, CB#7295, Chapel Hill, NC 27599-7295, USA.
出版信息
J Virol. 2007 May;81(10):5413-7. doi: 10.1128/JVI.02554-06. Epub 2007 Feb 28.
Abstract
Using DNA heteroduplex tracking assays, we characterized human immunodeficiency virus type 1 env V4/V5 genetic populations in multiple blood plasma samples collected over an average of 7 months from 24 chronically infected human subjects. We observed complex and dynamic V4/V5 genetic populations in most subjects. Comparisons of V4/V5 and V1/V2 population changes over the course of the study showed that major shifts in genetic populations frequently occurred in one region but not the other, and these observations were independently confirmed in one subject by single-genome sequencing. These results suggest that the V1/V2 and V4/V5 regions of env often evolve independently during chronic infection.
摘要
通过DNA异源双链追踪分析，我们对24名慢性感染人类受试者在平均7个月的时间里采集的多个血浆样本中的1型人类免疫缺陷病毒env V4/V5基因群体进行了特征分析。我们在大多数受试者中观察到了复杂且动态的V4/V5基因群体。在研究过程中对V4/V5和V1/V2群体变化的比较表明，基因群体的主要变化经常发生在一个区域而不是另一个区域，并且这些观察结果在一名受试者中通过单基因组测序得到了独立证实。这些结果表明，在慢性感染期间，env的V1/V2和V4/V5区域通常独立进化。
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