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本文引用的文献

1
Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity.1型人类免疫缺陷病毒的V1-V2包膜环序列在感染过程中会扩展并增加糖基化位点，这些修饰会影响抗体中和敏感性。
J Virol. 2006 Oct;80(19):9586-98. doi: 10.1128/JVI.00141-06.
2
Sequential turnover of human immunodeficiency virus type 1 env throughout the course of infection.人类免疫缺陷病毒1型env在感染全过程中的顺序性周转。
J Virol. 2006 Nov;80(21):10591-9. doi: 10.1128/JVI.00644-06. Epub 2006 Sep 6.
3
Distribution and three-dimensional structure of AIDS virus envelope spikes.艾滋病病毒包膜刺突的分布及三维结构
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GP120: target for neutralizing HIV-1 antibodies.糖蛋白120：HIV-1中和抗体的靶点。
Annu Rev Immunol. 2006;24:739-69. doi: 10.1146/annurev.immunol.24.021605.090557.
5
Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques.在猿猴/人类免疫缺陷病毒感染的猕猴中，1型人类免疫缺陷病毒包膜与接种病毒包膜分化过程中的一致变化模式。
J Virol. 2006 Jan;80(2):999-1014. doi: 10.1128/JVI.80.2.999-1014.2006.
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Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection.在近期的HIV感染过程中，中和抗体反应推动了1型人类免疫缺陷病毒包膜的演变。
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18514-9. doi: 10.1073/pnas.0504658102. Epub 2005 Dec 9.
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Compartmentalized human immunodeficiency virus type 1 present in cerebrospinal fluid is produced by short-lived cells.存在于脑脊液中的分隔化1型人类免疫缺陷病毒是由短命细胞产生的。
J Virol. 2005 Jul;79(13):7959-66. doi: 10.1128/JVI.79.13.7959-7966.2005.
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Structure of an unliganded simian immunodeficiency virus gp120 core.未结合配体的猿猴免疫缺陷病毒糖蛋白120核心的结构。
Nature. 2005 Feb 24;433(7028):834-41. doi: 10.1038/nature03327.
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Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis.标准基因分型分析会遗漏治疗经验丰富患者中多个相互关联的1型人类免疫缺陷病毒耐药突变。
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10
The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection.gp120的V1/V2结构域是原发性人类免疫缺陷病毒1型分离株对感染后通常诱导产生的抗体中和敏感性的全局调节因子。
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慢性感染期间人类免疫缺陷病毒1型env V1/V2和V4/V5高变区的独立进化

Independent evolution of human immunodeficiency virus type 1 env V1/V2 and V4/V5 hypervariable regions during chronic infection.

作者信息

Harrington Patrick R, Nelson Julie A E, Kitrinos Kathryn M, Swanstrom Ronald

机构信息

University of North Carolina at Chapel Hill, 22-062 Lineberger Cancer Center, CB#7295, Chapel Hill, NC 27599-7295, USA.

出版信息

J Virol. 2007 May;81(10):5413-7. doi: 10.1128/JVI.02554-06. Epub 2007 Feb 28.

DOI:10.1128/JVI.02554-06
PMID:17329337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1900199/
Abstract

Using DNA heteroduplex tracking assays, we characterized human immunodeficiency virus type 1 env V4/V5 genetic populations in multiple blood plasma samples collected over an average of 7 months from 24 chronically infected human subjects. We observed complex and dynamic V4/V5 genetic populations in most subjects. Comparisons of V4/V5 and V1/V2 population changes over the course of the study showed that major shifts in genetic populations frequently occurred in one region but not the other, and these observations were independently confirmed in one subject by single-genome sequencing. These results suggest that the V1/V2 and V4/V5 regions of env often evolve independently during chronic infection.

摘要

通过DNA异源双链追踪分析，我们对24名慢性感染人类受试者在平均7个月的时间里采集的多个血浆样本中的1型人类免疫缺陷病毒env V4/V5基因群体进行了特征分析。我们在大多数受试者中观察到了复杂且动态的V4/V5基因群体。在研究过程中对V4/V5和V1/V2群体变化的比较表明，基因群体的主要变化经常发生在一个区域而不是另一个区域，并且这些观察结果在一名受试者中通过单基因组测序得到了独立证实。这些结果表明，在慢性感染期间，env的V1/V2和V4/V5区域通常独立进化。