Krauss Michael, Haucke Volker
Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany.
EMBO Rep. 2007 Mar;8(3):241-6. doi: 10.1038/sj.embor.7400919.
Phosphoinositides (PIs) have long been known to have important roles in cell signalling. During the past decade, it has become clear that these lipids also act as constitutive signals that aid in defining organelle identity, and are short-lived recruiters and regulators of cytoskeletal and membrane dynamics. Recent studies have provided important clues as to how regulated activation of PI-metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different cell physiological functions.
长期以来，人们一直认为磷酸肌醇（PIs）在细胞信号传导中发挥着重要作用。在过去十年中，越来越清楚的是，这些脂质还作为组成信号，有助于定义细胞器的特性，并且是细胞骨架和膜动力学的短期招募者和调节者。最近的研究为PI代谢酶的调节激活及其结合蛋白的募集如何协同作用，将不同池的PIs靶向不同的细胞生理功能提供了重要线索。
