Overduin M, Cheever M L, Kutateladze T G
Department of Pharmacology and Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver 80262, USA.
Mol Interv. 2001 Aug;1(3):150-9.
When the outside of cell is stimulated,the inside generates a flurry of signals. Phosphates are sprinkled over lipids and proteins,where they are recognized within diverse signaling pathways. The kinases that congregate beneath the cell surface to provide the phosphate tags that mediate signaling have become major targets of new wave of drug design. Phosphoinositide signaling presents a particularly intriguing network whose many mysteries are now being unlocked. Research into protein domains that specifically recognize phosphoinositides have established the ENTH, FYVE,Phox,and pleckstrin homology domains s four cornerstones of phosphoinositide signaling.
当细胞外部受到刺激时，细胞内部会产生一连串的信号。磷酸盐附着在脂质和蛋白质上，在各种信号通路中被识别。聚集在细胞表面下方以提供介导信号传导的磷酸盐标签的激酶已成为新药设计浪潮的主要靶点。磷酸肌醇信号传导呈现出一个特别引人入胜的网络，其许多奥秘现在正在被揭开。对特异性识别磷酸肌醇的蛋白质结构域的研究已确定ENTH、FYVE、Phox和普列克底物蛋白同源结构域是磷酸肌醇信号传导的四个基石。
