Pizarro-Cerdá Javier, Cossart Pascale
Unité des Interactions Bactéries-Cellules/Unité INSERM 604, Institut Pasteur, 75724 Paris Cedex 15, France.
Nat Cell Biol. 2004 Nov;6(11):1026-33. doi: 10.1038/ncb1104-1026.
Phosphoinositides are short-lived lipids, whose production at specific membrane locations in the cell enables the tightly controlled recruitment or activation of diverse cellular effectors involved in processes such as cell motility or phagocytosis. Bacterial pathogens have evolved molecular mechanisms to subvert phosphoinositide metabolism in host cells, promoting (or blocking) their internalization into target tissues, and/or modifying the maturation fate of their proliferating compartments within the intracellular environment.
磷酸肌醇是寿命较短的脂质，其在细胞内特定膜位置的产生能够严格控制参与细胞运动或吞噬作用等过程的多种细胞效应器的募集或激活。细菌病原体已经进化出分子机制来破坏宿主细胞中的磷酸肌醇代谢，促进（或阻止）它们内化到靶组织中，和/或改变它们在细胞内环境中增殖区室的成熟命运。
