Welt Corrine K, Schneyer Alan L, Heist Kathleen, Mantzoros Christos S
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
J Assist Reprod Genet. 2003 Dec;20(12):495-501. doi: 10.1023/b:jarg.0000013649.38415.2a.
Previous studies suggest that follicular fluid leptin levels predict successful assisted reproduction. The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding.
Follicular fluid leptin, soluble leptin receptor, hormones, and oocyte quality were examined in 84 individual follicles from 30 women undergoing in vitro fertilization.
Follicular fluid leptin and soluble leptin receptor levels correlated inversely with each other (r = -0.354; p = 0.001). Follicular fluid leptin levels correlated with intrafollicular estradiol (r = 0.42; p < 0.001), progesterone (r = 0.48; p < 0.001), and androstenedione (r = 0.49; p < 0.001), whereas soluble leptin receptor levels correlated with activin (r = 0.38; p < 0.001) and follistatin (r = 0.35; p < 0.002). There was no relationship between follicular fluid leptin or soluble leptin receptor levels and pretreatment serum hormone levels, stimulated serum estradiol, follicle number, oocyte quality, fertilization, or embryo grade.
The data demonstrate that leptin and the soluble leptin receptor are highly interrelated with each other and with other intrafollicular hormones, but not with markers of oocyte quality, fertilization, or embryo grade.
先前的研究表明，卵泡液瘦素水平可预测辅助生殖的成功与否。本研究检测了卵泡内瘦素与可溶性瘦素受体、卵巢激素及卵母细胞质量之间的关系，以确定导致这一结果的潜在因素。
对30例行体外受精的女性的84个单个卵泡中的卵泡液瘦素、可溶性瘦素受体、激素及卵母细胞质量进行检测。
卵泡液瘦素水平与可溶性瘦素受体水平呈负相关（r = -0.354；p = 0.001）。卵泡液瘦素水平与卵泡内雌二醇（r = 0.42；p < 0.001）、孕酮（r = 0.48；p < 0.001）及雄烯二酮（r = 0.49；p < 0.001）相关，而可溶性瘦素受体水平与激活素（r = 0.38；p < 0.001）及卵泡抑素（r = 0.35；p < 0.002）相关。卵泡液瘦素或可溶性瘦素受体水平与预处理血清激素水平、刺激后的血清雌二醇、卵泡数量、卵母细胞质量、受精情况或胚胎等级之间无相关性。
数据表明，瘦素与可溶性瘦素受体之间以及它们与其他卵泡内激素之间高度相关，但与卵母细胞质量、受精或胚胎等级的标志物无关。
