Widdison A L, Karanjia N D, Alvarez C, Reber H A
Department of Surgery, UCLA School of Medicine.
Am J Surg. 1992 Jan;163(1):100-3; discussion 103-4. doi: 10.1016/0002-9610(92)90260-x.
We investigated the effect of levamisole on pancreatic infection in a model of acute pancreatitis (AP) in cats. Animals with and without AP received Escherichia coli intravenously. Blood was then taken at intervals for culture. AP reduced phagocytic function by 28% as measured by the rate of bacterial disappearance from the blood (p less than 0.03). In other cats, AP was induced, and E. coli were placed into the pancreatic duct. Levamisole was given orally in some cats; the remainder were untreated. Control cats (neither AP nor levamisole) also received E. coli. Seven days later, pancreases from all control cats were sterile. In AP cats, the pancreatic infection rate was 73%. Levamisole reduced the rate of infection to 22% (p less than 0.03). We concluded that phagocytic function was impaired in cats with AP. Levamisole reduced the rate of pancreatic infection.
我们在猫急性胰腺炎（AP）模型中研究了左旋咪唑对胰腺感染的影响。有或无AP的动物均静脉注射大肠杆菌。然后定期采血进行培养。通过血液中细菌消失率测量，AP使吞噬功能降低了28%（p<0.03）。在其他猫中，诱导产生AP，并将大肠杆菌注入胰管。部分猫口服左旋咪唑；其余未治疗。对照猫（既无AP也未用左旋咪唑）也接受大肠杆菌。7天后，所有对照猫的胰腺均无菌。在AP猫中，胰腺感染率为73%。左旋咪唑将感染率降至22%（p<0.03）。我们得出结论，AP猫的吞噬功能受损。左旋咪唑降低了胰腺感染率。
