Feest U, Kemper A, Nickel B, Rabe H, Koalick F
Krankenhaus für Psychiatrie und Neurologie Wilhelm Griesinger, Berlin, FRG.
Alcohol. 1992 Jan-Feb;9(1):49-52. doi: 10.1016/0741-8329(92)90009-y.
Salsolinol was measured in urine of alcoholics after one through four and after 21 days of withdrawal, in nonalcoholic controls with and without ingestion of alcohol and in young children. HPLC equipped with fluorescence detection was employed. There were no significant differences in salsolinol excretion rate between alcoholics and controls one day after alcohol deprivation. A significant difference in salsolinol output in urine of alcoholics between the first and the twenty-first day of withdrawal was found, but salsolinol output expressed as creatinine-related output did not change. There was no trend of urinary salsolinol excretion rate by alcoholics during the first 4 days of abstinence. The results indicate that the urinary salsolinol excretion rate and the creatinine-related salsolinol output are insufficient to distinguish between alcoholics and nonalcoholics.
在戒酒1至4天以及21天后，对酗酒者的尿液进行了去甲猪毛菜碱检测，同时也检测了摄入和未摄入酒精的非酗酒对照者以及幼儿的尿液。采用配备荧光检测的高效液相色谱法。在戒酒一天后，酗酒者和对照者之间的去甲猪毛菜碱排泄率没有显著差异。发现酗酒者在戒酒第一天和第二十一天的尿液中去甲猪毛菜碱产量存在显著差异，但以肌酐相关产量表示的去甲猪毛菜碱产量没有变化。在戒酒的前4天，酗酒者的尿去甲猪毛菜碱排泄率没有变化趋势。结果表明，尿去甲猪毛菜碱排泄率和肌酐相关的去甲猪毛菜碱产量不足以区分酗酒者和非酗酒者。
