Adachi J, Mizoi Y, Fukunaga T, Ueno Y, Imamichi H, Ninomiya I, Naito T
Alcohol. 1986 Nov-Dec;3(6):371-5. doi: 10.1016/0741-8329(86)90056-x.
Urinary excretion of salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) in 30 male alcoholic patients during the withdrawal period was determined. They were divided into two groups, i.e., Group A with 14 subjects had a high level of urinary salsolinol (51.9 +/- 40.8 ng/mg creatinine) on admission to a hospital, and Group B with 16 subjects showed a low level of the substance (3.9 +/- 1.9 ng/mg creatinine). Following a sustained drinking bout, urinary salsolinol in Group A declined to a normal level within a few days. We found that the subjects in Group A showed a greater excretion of urinary dopamine and norepinephrine than those in Group B. There were no differences between the two groups in levels of blood ethanol, serum GOT, GPT and gamma-GTP.
测定了30名男性酒精性患者戒断期内去甲猪毛菜碱（6,7-二羟基-1-甲基-1,2,3,4-四氢异喹啉）的尿排泄量。他们被分为两组，即入院时14名受试者组成的A组尿去甲猪毛菜碱水平较高（51.9±40.8 ng/mg肌酐），16名受试者组成的B组该物质水平较低（3.9±1.9 ng/mg肌酐）。持续饮酒一段时间后，A组尿去甲猪毛菜碱在几天内降至正常水平。我们发现，A组受试者尿多巴胺和去甲肾上腺素的排泄量高于B组。两组在血液乙醇、血清谷草转氨酶、谷丙转氨酶和γ-谷氨酰转肽酶水平上无差异。
