评估bcl-2蛋白表达及14;18易位作为滤泡性淋巴瘤预后标志物的情况。
Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
作者信息
Pezzella F, Jones M, Ralfkiaer E, Ersbøll J, Gatter K C, Mason D Y
机构信息
Department of Haematology, John Radcliffe Hospital, Oxford, UK.
出版信息
Br J Cancer. 1992 Jan;65(1):87-9. doi: 10.1038/bjc.1992.16.
Abstract
Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and without the translocation. However these results were based on small series of cases and on follow-up periods (no longer than 7 years) which are relatively short for a disease with such a slow clinical evolution. Here we report an investigation of 70 cases of follicular lymphoma with long term follow-up data (up to 17 years). This series has been studied for the presence of the 14;18 translocation and for the expression of bcl-2 protein. Our results show that there are no grounds for considering either the 14;18 translocation or the expression of the bcl-2 protein to be useful prognostic markers in clinical practice.
摘要
关于t(14;18)在滤泡性淋巴瘤中的预后意义，已发表了相互矛盾的结果：尤尼斯等人（1989年）报告称，其存在表明对治疗反应不佳且生存期短，而莱文等人（1988年）则表明有该易位和无该易位的病例在预后方面没有差异。然而，这些结果是基于少量病例系列以及随访期（不超过7年）得出的，对于这样一种临床进展缓慢的疾病来说，随访期相对较短。在此，我们报告一项对70例滤泡性淋巴瘤的调查，这些病例有长期随访数据（长达17年）。该系列已针对14;18易位的存在情况以及bcl-2蛋白的表达情况进行了研究。我们的结果表明，在临床实践中，没有理由认为14;18易位或bcl-2蛋白的表达是有用的预后标志物。
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