• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Detection of bcl-2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis.

作者信息

Yuan R, Dowling P, Zucca E, Diggelmann H, Cavalli F

机构信息

Department of Medical Oncology, Ospedale San Giovanni, Bellinzona, Switzerland.

出版信息

Br J Cancer. 1993 May;67(5):922-5. doi: 10.1038/bjc.1993.171.

DOI:10.1038/bjc.1993.171
PMID:8494725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968466/
Abstract

The capacity to detect t(14;18) breakpoints in non-Hodgkin's lymphoma (NHL) peripheral blood and bone marrow was studied by DNA PCR. We studied 33 patients with follicular lymphoma (FL) (Working Formulation subtypes B, C, D) and 38 patients with intermediate-grade NHL (subtypes F, G). In the FL subgroup, 86% of the morphologically-positive bone marrow patients had amplifiable t(14;18) breakpoints by PCR. Remarkably, of 19 FL patients with 'negative' bone marrows, 11 (58%) were PCR-positive. In addition, half of the early clinical stage patients (I and II) had detectable breakpoints in their bone marrow DNA. Samples from NHL patients with intermediate-grade disease exhibit the same phenomena but at a considerably lower frequency. Paired peripheral blood and bone marrow samples were available at diagnosis in a subset of 56 patients. The concordance between bone marrow and peripheral blood PCR findings was high, with peripheral blood of 55/56 showing the same PCR results as the corresponding bone marrow.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f16/1968466/3bc428e7f507/brjcancer00207-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f16/1968466/3bc428e7f507/brjcancer00207-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f16/1968466/3bc428e7f507/brjcancer00207-0057-a.jpg

相似文献

1
Detection of bcl-2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis.
Br J Cancer. 1993 May;67(5):922-5. doi: 10.1038/bjc.1993.171.
2
Molecular monitoring of low grade non-Hodgkin's lymphoma by gene amplification.通过基因扩增对低度非霍奇金淋巴瘤进行分子监测。
Br J Cancer. 1991 Dec;64(6):1161-3. doi: 10.1038/bjc.1991.482.
3
Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia.伴有滤泡增生的良性淋巴组织中的Bcl-2/JH重排
Oncogene. 1991 Dec;6(12):2271-6.
4
Detection of t(14;18) carrying cells in bone marrow and peripheral blood from patients affected by non-lymphoid diseases.非淋巴性疾病患者骨髓和外周血中携带t(14;18)细胞的检测。
Mol Pathol. 1998 Dec;51(6):333-8. doi: 10.1136/mp.51.6.333.
5
Eradication of polymerase chain reaction detectable immunoglobulin gene rearrangement in non-Hodgkin's lymphoma is associated with decreased relapse after autologous bone marrow transplantation.非霍奇金淋巴瘤中聚合酶链反应可检测到的免疫球蛋白基因重排的消除与自体骨髓移植后复发率降低相关。
Blood. 1996 Nov 1;88(9):3314-22.
6
Occult lymphoma cells prevalent in autologous marrow from non-Hodgkin's diffuse lymphoma.隐匿性淋巴瘤细胞在非霍奇金弥漫性淋巴瘤患者的自体骨髓中普遍存在。
Am J Hematol. 2003 May;73(1):1-11. doi: 10.1002/ajh.10308.
7
Quantitative PCR detection of t(14;18) bcl-2/JH fusion sequences in follicular lymphoma patients: comparison of peripheral blood and bone marrow aspirate samples.滤泡性淋巴瘤患者中t(14;18) bcl-2/JH融合序列的定量PCR检测：外周血与骨髓穿刺样本的比较
J Mol Diagn. 2004 Nov;6(4):396-400. doi: 10.1016/S1525-1578(10)60537-5.
8
Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma.t(11;14)连接处的模板化核苷酸添加及免疫球蛋白JH基因利用：对易位机制及套细胞淋巴瘤起源的意义
Cancer Res. 2001 Feb 15;61(4):1629-36.
9
Multiplex PCR for the detection of BCL-1/IGH and BCL-2/IGH gene rearrangements--clinical validation in a prospective study of blood and bone marrow in 258 patients with or suspected of non-Hodgkin's lymphoma.
Acta Oncol. 2007;46(1):21-30. doi: 10.1080/02841860600681551.
10
Polymerase chain reaction detection of cells carrying t(14;18) in bone marrow of patients with follicular and diffuse large B-cell lymphoma: the importance of analysis at diagnosis and significance of long-term follow-up.聚合酶链反应检测滤泡性和弥漫性大B细胞淋巴瘤患者骨髓中携带t(14;18)的细胞：诊断时分析的重要性及长期随访的意义
Neoplasma. 2001;48(6):501-5.

引用本文的文献

1
A transcriptional signature associated with non-Hodgkin lymphoma in the blood of patients with Q fever.与 Q 热患者血液中的非霍奇金淋巴瘤相关的转录特征。
PLoS One. 2019 Jun 10;14(6):e0217542. doi: 10.1371/journal.pone.0217542. eCollection 2019.
2
Detection of minimal residual disease in hematopoietic progenitor cell harvests: lack of predictive value of peripheral blood and bone marrow analysis in mantle cell and indolent lymphoma.造血祖细胞采集物中微小残留病的检测：外周血和骨髓分析在套细胞淋巴瘤和惰性淋巴瘤中缺乏预测价值。
Am J Blood Res. 2012;2(2):105-12. Epub 2012 Apr 15.
3
Association of clinical status of follicular lymphoma patients after autologous stem cell transplant and quantitative assessment of lymphoma in blood and bone marrow as measured by SYBR Green I polymerase chain reaction.

本文引用的文献

1
Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma.非霍奇金淋巴瘤组织学亚型中的独特染色体异常。
N Engl J Med. 1982 Nov 11;307(20):1231-6. doi: 10.1056/NEJM198211113072002.
2
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.具有t(14;18)染色体易位的肿瘤性B细胞染色体断点的克隆。
Science. 1984 Nov 30;226(4678):1097-9. doi: 10.1126/science.6093263.
3
Incidence cytology, and histopathology of non-Hodgkin's lymphomas in the bone marrow.
自体干细胞移植后滤泡性淋巴瘤患者的临床状态与通过SYBR Green I聚合酶链反应测量的血液和骨髓中淋巴瘤定量评估的相关性。
J Mol Diagn. 2006 Feb;8(1):40-50. doi: 10.2353/jmoldx.2006.050050.
4
Clinical relevance of bcl-2(MBR)/J(H) rearrangement detected by polymerase chain reaction in the peripheral blood of patients with follicular lymphoma.聚合酶链反应检测滤泡性淋巴瘤患者外周血中bcl-2(MBR)/J(H)重排的临床意义
Br J Cancer. 1997;76(1):36-9. doi: 10.1038/bjc.1997.332.
5
Immunocytochemical detection of breast cancer cells in marrow and peripheral blood of patients undergoing high dose chemotherapy with autologous stem cell support.接受高剂量化疗并自体干细胞支持的患者骨髓和外周血中乳腺癌细胞的免疫细胞化学检测。
Breast Cancer Res Treat. 1996;41(1):1-13. doi: 10.1007/BF01807031.
6
Molecular pathology of low grade malignant lymphomas.低度恶性淋巴瘤的分子病理学
Med Oncol. 1995 Sep;12(3):167-76. doi: 10.1007/BF01571194.
Cancer. 1974 May;33(5):1382-98. doi: 10.1002/1097-0142(197405)33:5<1382::aid-cncr2820330525>3.0.co;2-2.
4
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.克隆t(14;18) 人类淋巴瘤的染色体断点：聚集在14号染色体上的JH周围以及18号染色体上一个转录单位附近。
Cell. 1985 Jul;41(3):899-906. doi: 10.1016/s0092-8674(85)80070-2.
5
Involvement of the bcl-2 gene in human follicular lymphoma.bcl-2基因与人类滤泡性淋巴瘤的关系。
Science. 1985 Jun 21;228(4706):1440-3. doi: 10.1126/science.3874430.
6
Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas.恶性淋巴瘤中t(14;18)染色体易位的分子分析。
N Engl J Med. 1987 Nov 5;317(19):1185-9. doi: 10.1056/NEJM198711053171904.
7
The gene located at chromosome 18 band q21 is rearranged in uncultured diffuse lymphomas as well as follicular lymphomas.位于18号染色体q21带的基因在未经培养的弥漫性淋巴瘤以及滤泡性淋巴瘤中发生重排。
Blood. 1987 Jul;70(1):90-5.
8
Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.与t(14;18)染色体易位相关的bcl-2蛋白在非霍奇金淋巴瘤中的表达。
N Engl J Med. 1988 Jun 23;318(25):1638-44. doi: 10.1056/NEJM198806233182502.
9
Detection of occult follicular lymphoma by specific DNA amplification.通过特异性DNA扩增检测隐匿性滤泡性淋巴瘤
Blood. 1988 Nov;72(5):1822-5.
10
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.t(14;18)染色体断点的热稳定DNA聚合酶链扩增及微小残留病的检测
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4869-73. doi: 10.1073/pnas.85.13.4869.