El Fray M, Feldmann M, Ziegler G, Prowans P
Szczecin University of Technology, Polymer Institute, Szczecin, Poland.
J Mater Sci Mater Med. 2007 Mar;18(3):501-6. doi: 10.1007/s10856-007-2010-4.
There is a recognized need for improved treatment of osteoarthritis of the finger joints disease. Joint fusions are commonly used for treating the pain and potential deformity of arthritis. At severe deformity, artificial joint replacement is required. The most widely used are space-filler type joints made of high performance silicone rubber. One of the problems that occurs with these artificial replacements is that they can fail, because silicone elastomer used for their fabrication is relatively weak material and show to break apart and fragment. We have recently developed novel poly(aliphatic/aromatic-ester) (PED) material of sufficient mechanical properties and excellent flexibility. To enhance the bioactivity of these polymers (PED) and bone-bonding properties, PED/beta-TCP composites were prepared. The ceramic particles were homogeneously distributed during conventional blending and showed good adhesion to the polymer matrix. The thermal characteristics and mechanical properties of the composites were investigated as a function of beta-TCP content. The Youngs modulus and the yield strength of the composites increased with the increase in beta-TCP volume while the tensile strength and fracture strain decreased. In vitro investigations demonstrated an increase in cytocompatibility with increasing amount of beta-TCP up to 20 vol%.
人们已经认识到需要改进手指关节骨关节炎疾病的治疗方法。关节融合术常用于治疗关节炎的疼痛和潜在畸形。在严重畸形的情况下，则需要进行人工关节置换。使用最广泛的是由高性能硅橡胶制成的填充型关节。这些人工关节置换出现的问题之一是它们可能会失效，因为用于制造它们的硅橡胶弹性体是相对较弱的材料，容易破碎和断裂。我们最近开发了一种具有足够机械性能和出色柔韧性的新型聚（脂肪族/芳香族酯）（PED）材料。为了提高这些聚合物（PED）的生物活性和骨结合性能，制备了PED/β-TCP复合材料。在常规共混过程中，陶瓷颗粒均匀分布，并且与聚合物基体表现出良好的附着力。研究了复合材料的热特性和机械性能与β-TCP含量的关系。复合材料的杨氏模量和屈服强度随着β-TCP体积的增加而增加，而拉伸强度和断裂应变则降低。体外研究表明，随着β-TCP含量增加至20体积%，细胞相容性增加。
