Roberts Angela C, Tomic Davorka L, Parkinson Caroline H, Roeling Tom A, Cutter David J, Robbins Trevor W, Everitt Barry J
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK.
J Comp Neurol. 2007 May 1;502(1):86-112. doi: 10.1002/cne.21300.
The cortical and subcortical forebrain connections of the marmoset prefrontal cortex (PFC) were examined by injecting the retrograde tracer, choleratoxin, and the anterograde tracer, biotin dextran amine, into four sites within the PFC. Two of the sites, the lateral and orbital regions, had previously been shown to provide functionally dissociable contributions to distinct forms of behavioral flexibility, attentional set-shifting and discrimination reversal learning, respectively. The dysgranular and agranular regions lying on the orbital and medial surfaces of the frontal lobes were most closely connected with limbic structures including cingulate cortex, amygdala, parahippocampal cortex, subiculum, hippocampus, hypothalamus, medial caudate nucleus, and nucleus accumbens as well as the magnocellular division of the mediodorsal nucleus of the thalamus and midline thalamic nuclei, consistent with findings in the rhesus monkey. In contrast, the granular region on the dorsal surface closely resembled area 8Ad in macaques and had connections restricted to posterior parietal cortex primarily associated with visuospatial functions. However, it also had connections with limbic cortex, including retrosplenial and caudal cingulate cortex as well as auditory processing regions in the superior temporal cortex. The granular region on the lateral convexity had the most extensive connections. Based on its architectonics and functionality, it resembled areas 12/45 in macaques. It had connections with high-order visual processing regions in the inferotemporal cortex and posterior parietal cortex, higher-order auditory and polymodal processing regions in the superior temporal cortex. In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex.
通过将逆行示踪剂霍乱毒素和顺行示踪剂生物素葡聚糖胺注入狨猴前额叶皮层（PFC）内的四个位点，对其皮质和皮质下前脑连接进行了研究。其中两个位点，即外侧和眶部区域，先前已被证明分别对不同形式的行为灵活性、注意力转换和辨别逆转学习提供功能上可分离的贡献。位于额叶眶面和内侧面的颗粒减少区和无颗粒区与边缘结构联系最为紧密，这些边缘结构包括扣带回皮质、杏仁核、海马旁皮质、海马下托、海马、下丘脑、内侧尾状核、伏隔核，以及丘脑背内侧核的大细胞部和丘脑中线核，这与恒河猴的研究结果一致。相比之下，背侧表面的颗粒区与猕猴的8Ad区非常相似，其连接仅限于主要与视觉空间功能相关的顶叶后皮质。然而，它也与边缘皮质有连接，包括压后皮质和尾侧扣带回皮质以及颞上皮质的听觉处理区域。外侧凸面的颗粒区连接最为广泛。基于其结构和功能，它类似于猕猴的12/45区。它与颞下皮质的高级视觉处理区域和顶叶后皮质、颞上皮质的高级听觉和多模态处理区域有连接。此外，它还与包括杏仁核、海马旁皮质、扣带回和压后皮质在内的边缘区域有广泛连接。
