解析物和保护素：解析生物学的天然药效团。
Resolvins and protectins: natural pharmacophores for resolution biology.
机构信息
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):327-32. doi: 10.1016/j.plefa.2010.02.003. Epub 2010 Mar 15.
Abstract
Dietary ingestion of fish is associated with a reduced risk for many common human illnesses. Fish oils are enriched with n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. Resolvins and protectins are newly discovered mediators that are enzymatically generated from these n-3 fatty acid precursors to orchestrate inflammation resolution. These natural compounds and their mimetics are providing intriguing evidence in model systems and translational research for cellular and molecular mechanisms that are active during catabasis. This review provides information on the biosynthesis and actions of these recently identified chemical mediators with particular reference to resolution of mucosal inflammatory responses.
摘要
饮食中摄入鱼类与许多常见人类疾病的风险降低有关。鱼油富含 n-3 多不饱和脂肪酸二十碳五烯酸和二十二碳六烯酸。解析素和保护素是新发现的介质，它们是由这些 n-3 脂肪酸前体酶促生成的，用于协调炎症的消退。这些天然化合物及其类似物在模型系统和转化研究中为细胞和分子机制提供了有趣的证据，这些机制在衰退期是活跃的。本文综述了这些最近发现的化学介质的生物合成和作用，特别参考了黏膜炎症反应的消退。
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Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Am J Respir Crit Care Med. 2008 Sep 15;178(6):574-82. doi: 10.1164/rccm.200801-061OC. Epub 2008 Jun 26.
2
Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation.
Nat Immunol. 2008 Aug;9(8):873-9. doi: 10.1038/ni.1627. Epub 2008 Jun 22.
3
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.
Nat Rev Immunol. 2008 May;8(5):349-61. doi: 10.1038/nri2294.
4
Synthetic chemerin-derived peptides suppress inflammation through ChemR23.
J Exp Med. 2008 Apr 14;205(4):767-75. doi: 10.1084/jem.20071601. Epub 2008 Apr 7.
5
The role of lipoxin A4 in exercise-induced bronchoconstriction in asthma.
J Asthma. 2008 Mar;45(2):161-4. doi: 10.1080/02770900701847068.
6
Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease.
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J Immunol. 2007 Nov 15;179(10):7021-9. doi: 10.4049/jimmunol.179.10.7021.
8
Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus.
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9
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Clin Exp Allergy. 2007 Oct;37(10):1494-501. doi: 10.1111/j.1365-2222.2007.02806.x.
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