Stoupel E, Monselise Y, Lahav J
Division of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Israel.
J Basic Clin Physiol Pharmacol. 2006;17(4):269-78. doi: 10.1515/jbcpp.2006.17.4.269.
The possible relation between various biological or medical phenomena and changes in environmental physical activity, such as Solar, Geomagnetic Activity (GMA); Cosmic Ray; Proton, and other particle flux, have been reported. These phenomena seem to be reflected, among others, in the immune system, resulting in changes in immunoglobulin (Ig) levels or outbursts of epidemics.
to examine a possible association of GMA with another aspect of the immune system--autoimmunity. Fluctuations of levels of anticardiolipin (IgG; IgM, IgA subtypes) and lupus anticoagulant (Kaulin clotting time and Dilute Russell's viper venom time) autoantibodies, serving as anticardiolipin syndrome (ACLS) markers, were monitored during days of severe GMA storms and compared with those of lowest/quiet GMA days. Cosmophysical data were obtained from the NOAA National Space Service Center and the National Geophysical Data Center, USA.
A significant rise in the levels of anti beta2Gp1-IgA (p = 0.0001); and KCT (p = 0.019) was observed on days of the GMA storms.
On days of major GMA storms, significant changes in the autoimmune marker levels of ACLS were observed compared with quiet days. An involvement of those changes in clinical events related to GMA storms is possible.
已报道了各种生物或医学现象与环境物理活动变化之间的可能关系，如太阳活动、地磁活动（GMA）、宇宙射线、质子及其他粒子通量。这些现象似乎在免疫系统等方面有所体现，导致免疫球蛋白（Ig）水平变化或疫情爆发。
研究GMA与免疫系统的另一个方面——自身免疫之间的可能关联。在严重GMA风暴期间监测作为抗心磷脂综合征（ACLS）标志物的抗心磷脂（IgG、IgM、IgA亚型）和狼疮抗凝物（高岭土凝血时间和稀释蝰蛇毒时间）自身抗体水平的波动，并与最低/平静GMA日的水平进行比较。宇宙物理数据来自美国国家海洋和大气管理局国家空间服务中心和国家地球物理数据中心。
在GMA风暴日观察到抗β2Gp1-IgA水平（p = 0.0001）和高岭土凝血时间（KCT，p = 0.019）显著升高。
与平静日相比，在主要GMA风暴日观察到ACLS自身免疫标志物水平有显著变化。这些变化可能与GMA风暴相关的临床事件有关。
