Department of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States.
Department of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States.
Environ Res. 2022 Mar;204(Pt B):112066. doi: 10.1016/j.envres.2021.112066. Epub 2021 Sep 17.
It has been hypothesized that solar and geomagnetic activity can affect the function of the autonomic nervous system (ANS) and melatonin secretion, both of which may influence immune response. We investigated the association between solar geomagnetic activity and white blood cell counts in the Normative Aging Study (NAS) Cohort between 2000 and 2013. Linear mixed effects models with moving day averages ranging from 0 to 28 days were used to evaluate the effects of solar activity measures, interplanetary magnetic field (IMF), and sunspot number (SSN), and a measure of geomagnetic activity, K Index (K), on total white blood cell (WBC), neutrophil, monocytes, lymphocyte, eosinophil, and basophil concentrations. After adjusting for demographic and health-related factors, there were consistently significant associations between IMF, SSN, and K index, with reductions in total WBC, neutrophils, and basophil counts. These associations were stronger with longer moving averages. The associations were similar after adjusting for ambient air particulate pollution and particle radioactivity. Our findings suggest that periods of increased solar and geomagnetic activity result in lower WBC, neutrophil, and basophil counts that may contribute to mil mild immune suppression.
据推测，太阳和地磁活动会影响自主神经系统（ANS）的功能和褪黑素的分泌，而这两者都可能影响免疫反应。我们在 2000 年至 2013 年间，在“正常衰老研究（NAS）队列”中调查了太阳地磁活动与白细胞计数之间的关联。我们采用移动日平均值在 0 至 28 天范围内的线性混合效应模型，来评估太阳活动指标、行星际磁场（IMF）和太阳黑子数（SSN），以及地磁活动指标 K 指数对总白细胞（WBC）、中性粒细胞、单核细胞、淋巴细胞、嗜酸性粒细胞和嗜碱性粒细胞浓度的影响。在调整了人口统计学和与健康相关的因素后，IMF、SSN 和 K 指数与总 WBC、中性粒细胞和嗜碱性粒细胞计数的减少之间始终存在显著关联。移动平均值越长，这些关联就越强。在调整了环境空气颗粒物污染和放射性颗粒物后，这些关联仍然相似。我们的研究结果表明，太阳和地磁活动增强的时期会导致 WBC、中性粒细胞和嗜碱性粒细胞计数降低，这可能导致免疫功能轻度抑制。
