Alster Tina S, Tanzi Elizabeth L, Lazarus Melissa
Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
Dermatol Surg. 2007 Mar;33(3):295-9. doi: 10.1111/j.1524-4725.2007.33059.x.
Patients with atrophic scars commonly seek treatment for their removal but are often concerned about the prolonged recovery, short-lived results, and/or ineffectiveness of available therapies. A novel treatment using a 1,550-nm erbium-doped fiber laser to induce fractional photothermolysis of treated skin has been used to resurface photodamaged skin but has not been studied previously in patients with atrophic scars to determine its effectiveness for this condition.
To determine the effectiveness and safety of 1,550-nm erbium-doped fiber laser treatment on atrophic scars.
Fifty-three patients (skin phototypes I-V) with mild to moderate atrophic facial acne scars received monthly treatment with a 1,550-nm erbium-doped fiber laser (Fraxel, Reliant Technologies Inc., San Diego, CA). Clinical response to treatment was determined at each treatment visit and 6 months after the final treatment session by two independent assessors using a quartile grading scale. Side effects and patient satisfaction were monitored at each follow-up visit.
Clinical improvement averaged 51% to 75% in nearly 90% of patients after three monthly laser treatments. Mean improvement scores increased proportionately with each successive laser session. Clinical response rates were independent of age, gender, or skin phototype. Side effects included transient erythema and edema in most patients, but no dyspigmentation, ulceration, or scarring.
Atrophic scars can be effectively and safely reduced with 1,550-nm erbium-doped fiber laser treatment.
萎缩性瘢痕患者通常会寻求去除瘢痕的治疗方法，但他们常常担心现有治疗方法恢复时间长、效果维持时间短和/或无效。一种使用1550纳米掺铒光纤激光器对治疗皮肤进行分次光热解的新型治疗方法已被用于改善光损伤皮肤，但此前尚未在萎缩性瘢痕患者中进行研究以确定其对这种情况的有效性。
确定1550纳米掺铒光纤激光治疗萎缩性瘢痕的有效性和安全性。
53例（皮肤光型I - V）轻至中度面部痤疮萎缩性瘢痕患者每月接受一次1550纳米掺铒光纤激光（飞梭激光，瑞蓝科技公司，加利福尼亚州圣地亚哥）治疗。由两名独立评估人员在每次治疗时以及最后一次治疗后6个月使用四分位数分级量表确定治疗的临床反应。在每次随访时监测副作用和患者满意度。
经过三个月的激光治疗后，近90%的患者临床改善平均达到51%至75%。每次连续激光治疗后平均改善分数成比例增加。临床反应率与年龄、性别或皮肤光型无关。副作用包括大多数患者出现短暂的红斑和水肿，但无色素沉着异常、溃疡或瘢痕形成。
1550纳米掺铒光纤激光治疗可有效且安全地减轻萎缩性瘢痕。
