Martinez David Alvarez, Laffitte Emmanuel, Kositratna Garuna, Laubach Hans-Joachim
Division of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.
Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital Research Institute, Charlestown, Boston, MA, United States.
Ann Dermatol. 2022 Aug;34(4):301-304. doi: 10.5021/ad.19.291.
Cutaneous discoid lupus erythematosus (CDLE) is a chronic inflammatory skin disease often resulting in permanent scarring of the affected area. Fractional photothermolysis (FP) is a well-known inducer of tissue regeneration by wounding the skin in a fractional pattern, hence inducing a well defined, wound healing response. It has been used clinically to treat atrophic as well as hypertrophic scars and also fibrotic diseases like morphea since more than a decade. We report a case of a young female patient treated with three sessions of ablative FP for stable atrophic scars due to CDLE affection of the upper left and right cheeks. After the last treatment, no side effects were observed. At the 13-month follow-up visit, the treated atrophic scars showed satisfying improvement for the patient. Skin texture, relief, color, and overall cosmetic appearance were all rated as improved by three independent dermatologists. No signs of unwanted side effects were observed at any time point. This case report should be followed up with a larger case series or ideally a prospective randomized clinical trial to better establish FP as a safe and effective tool to treat reminiscent scars after CDLE.
皮肤盘状红斑狼疮（CDLE）是一种慢性炎症性皮肤病，常导致受累区域永久性瘢痕形成。分次光热解（FP）是一种通过以分次模式损伤皮肤来诱导组织再生的知名方法，从而引发明确的伤口愈合反应。十多年来，它已在临床上用于治疗萎缩性和肥厚性瘢痕以及诸如硬斑病等纤维化疾病。我们报告了一例年轻女性患者，因左上脸颊和右上脸颊受CDLE影响出现稳定的萎缩性瘢痕，接受了三次剥脱性FP治疗。最后一次治疗后，未观察到副作用。在13个月的随访中，治疗后的萎缩性瘢痕对患者而言显示出令人满意的改善。三位独立的皮肤科医生将皮肤质地、平整度、颜色和整体美容外观均评定为有所改善。在任何时间点均未观察到不良副作用迹象。本病例报告应通过更大规模的病例系列或理想情况下的前瞻性随机临床试验进行随访，以更好地确立FP作为治疗CDLE后遗留瘢痕的安全有效工具。
