Weiss Carlos O, Fried Linda P, Bandeen-Roche Karen
Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):167-73. doi: 10.1093/gerona/62.2.167.
Preventing mobility disability depends on matching interventions to individual needs. The purpose of this study is to improve targeting by determining whether mobility performance is associated with, and predicts, mobility disability hierarchically. The hypothesis is that poorer performance tested by more demanding tasks is more strongly associated with current and future mobility "limitation" (self-reported task modification or difficulty) than is that tested by less demanding tasks, in a graded manner.
Data come from the Women's Health and Aging Study II (n = 436) at baseline and at 36-month follow-up. Logistic and multinomial regression models examined associations between performance on mobility tests and reported limitation in walking one-half mile, adjusting for risk factors for disability.
We found that 76.6% of prevalent and 88.4% of new-onset self-reported limitation fit within the hypothesized hierarchical pattern. The estimated strength of association between a decrement in lower extremity performance and reported limitation increased with task demand for the primary outcome, reported limitation in walking one-half mile. For example, the odds ratios for prevalent report of walking limitation, versus no limitation, for 10% lower performance walking, dressing, repeating chair stands, and climbing, respectively, were 1.05 (95% confidence interval, 0.97-1.17), 1.08 (1.00-1.16), 1.15 (1.06-1.25), and 1.22 (1.12-1.33).
This study partially supports the hypothesis that mobility performance tends to follow a hierarchical pattern. For studying mild mobility disability, walking speed may not be as useful as more demanding tests. Identifying declines in performance through more demanding tests such as climbing should improve the ability to target preventive interventions to individuals at risk of mild mobility decline within a high-functioning population.
预防行动能力残疾取决于使干预措施与个体需求相匹配。本研究的目的是通过分层确定行动能力表现是否与行动能力残疾相关并对其进行预测,从而改善干预措施的针对性。假设是,与要求较低的任务所测试的表现相比,要求较高的任务所测试的较差表现与当前和未来的行动“受限”(自我报告的任务调整或困难)的关联更为紧密,且呈梯度变化。
数据来自女性健康与衰老研究II(n = 436)的基线和36个月随访。逻辑回归和多项回归模型检验了行动测试表现与报告的半英里步行受限之间的关联,并对残疾风险因素进行了调整。
我们发现,76.6%的现患和88.4%的新发性自我报告受限符合假设的分层模式。下肢表现下降与报告受限之间的估计关联强度随主要结局(报告的半英里步行受限)的任务需求增加而增加。例如,与无步行受限报告相比,步行、穿衣、重复起坐和攀爬表现分别降低10%时,现患步行受限报告的比值比分别为1.05(95%置信区间,0.97 - 1.17)、1.08(1.00 - 1.16)、1.15(1.06 - 1.25)和1.22(1.12 - 1.33)。
本研究部分支持了行动能力表现倾向于遵循分层模式的假设。对于研究轻度行动能力残疾,步行速度可能不如要求更高的测试有用。通过攀爬等要求更高的测试来识别表现下降,应能提高针对高功能人群中轻度行动能力下降风险个体进行预防性干预的能力。