Intramural Research Program, National Institute on Aging, Baltimore, Maryland.
J Am Geriatr Soc. 2014 Feb;62(2):347-51. doi: 10.1111/jgs.12638. Epub 2014 Jan 13.
To evaluate the criterion validity of two measures of fatigability, defined as performance deterioration or perceived effort to perform a standardized task.
Cross-sectional analysis of data from the Baltimore Longitudinal Study of Aging (BLSA).
National Institute on Aging, Intramural Research Program, Clinical Research Unit, Baltimore, Maryland.
Six hundred five men (53.7%) and women aged 65 to 97 participating in the BLSA and eligible for endurance walk testing without a walking aid.
Fatigability was assessed using completion status and lap times from a 400-m walk performed "as quickly as possible" and perceived exertion rating using the Borg scale (range 6-20) after 5 minutes of treadmill walking at 1.5 miles per hour (0.67 m/s). Criterion measures included self-report of tiredness, level of weakness and energy in past month, and walking ability and objective measures of usual and fast gait speed, time to complete 10 chair stands, and grip strength. Covariates included age, race, sex, obesity, smoking status, and walking activity.
Of mobility-intact older persons, 23% exhibited performance deterioration (slowed or stopped) during the 400-m walk, and one-third reported more than very light exertion after a 5-minute slow walk. Slowing was strongly associated with self-reported fatigue and walking ability but weakly associated with performance-based mobility measures. High perceived exertion was associated with tiredness, weakness, and reported and observed mobility deficits.
Slowing down may have low sensitivity for identifying fatigability in older persons, but ascertaining perceived exertion during a defined workload shows promise. In seemingly healthy, motivated individuals, fatigue and fatigability were common and may affect socially meaningful mobility behaviors. Assessment of fatigability in well-elderly examinations may help identify threats to independent functioning earlier in the decline process.
评估两种疲劳测量方法的标准效度，疲劳定义为执行标准化任务时的表现下降或感知到的努力程度。
巴尔的摩老龄化纵向研究（BLSA）数据的横断面分析。
马里兰州巴尔的摩市，美国国立卫生研究院，院内研究计划，临床研究单位。
605 名年龄在 65 岁至 97 岁之间的男性（53.7%）和女性，他们参加了 BLSA，并且有资格在没有助行器的情况下进行耐力行走测试。
使用在 400 米快走测试中的完成状态和圈数来评估疲劳，参与者需要“尽可能快”地完成 400 米快走，同时使用 Borg 量表（范围 6-20）评估在 1.5 英里/小时（0.67 米/秒）的跑步机上行走 5 分钟后的感知用力程度。标准测量包括过去一个月的疲劳感、虚弱和精力水平、行走能力以及通常和快速行走速度、完成 10 次椅子站立所需时间和握力的客观测量。协变量包括年龄、种族、性别、肥胖、吸烟状况和行走活动。
在行动能力完好的老年人中，23%的人在 400 米快走中表现出运动能力下降（减慢或停止），三分之一的人在 5 分钟的慢走后报告用力程度超过了非常轻。速度减慢与自我报告的疲劳和行走能力密切相关，但与基于表现的行动能力测量相关较弱。高感知用力与疲劳、虚弱以及报告和观察到的行动能力缺陷相关。
在老年人中，速度减慢可能对识别疲劳的敏感性较低，但在定义工作量期间确定感知用力可能具有前景。在看似健康、积极的个体中，疲劳和疲劳感很常见，可能会影响到具有社会意义的行动能力行为。在对健康老年人的检查中评估疲劳感可能有助于在下降过程的早期更早地识别对独立功能的威胁。
