Engin-Ustün Yaprak, Ustün Yusuf, Karabulut Aysun Bay, Ozkaplan Esra, Meydanli M Mutlu, Kafkasli Ayşe
Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey.
Gynecol Obstet Invest. 2007;64(2):117-20. doi: 10.1159/000100329.
The purpose of this study was to examine serum amyloid A (SAA) levels in normal pregnant and pre-eclamptic women.
SAA levels were measured in 25 normotensive and 25 pre-eclamptic pregnant women by enzyme linked immuno-sorbent assay.
In pre-eclampsia, SAA level and C-reactive protein (CRP) averaged 28.2 (7.2-135) ng/l and 21 (6.13-91) mg/l, respectively, which were significantly higher than those of normal pregnancy (7.8 [4.65-24.6] ng/l and 6.05 [0.3-19] mg/l, respectively) (p < 0.05). In addition, SAA level was positively correlated to CRP (r = 0.468, p < 0.05).
Marked increases of both SAA level and CRP in pre-eclampsia, and their inter-relation, may at least in part contribute to the pathogenesis of pre-eclampsia.
本研究旨在检测正常孕妇和子痫前期孕妇的血清淀粉样蛋白A（SAA）水平。
采用酶联免疫吸附测定法测量25例血压正常的孕妇和25例子痫前期孕妇的SAA水平。
子痫前期患者的SAA水平和C反应蛋白（CRP）平均分别为28.2（7.2 - 135）ng/l和21（6.13 - 91）mg/l，显著高于正常妊娠孕妇（分别为7.8 [4.65 - 24.6] ng/l和6.05 [0.3 - 19] mg/l）（p < 0.05）。此外，SAA水平与CRP呈正相关（r = 0.468，p < 0.05）。
子痫前期患者的SAA水平和CRP均显著升高，且二者存在相互关系，这可能至少在一定程度上导致了子痫前期的发病机制。
