Mausbach Brent T, Harvey Phillip D, Goldman Sherry R, Jeste Dilip V, Patterson Thomas L
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0680, USA.
Schizophr Bull. 2007 Nov;33(6):1364-72. doi: 10.1093/schbul/sbm014. Epub 2007 Mar 6.
We developed and tested the validity of a brief scale to assess everyday functioning in persons with serious mental illness. A sample of 434 adults with schizophrenia or schizoaffective disorder were administered the University of California, San Diego, Performance-Based Skills Assessment (UPSA), which assesses functional skills in 5 areas of life functioning (eg, finances and planning). Through use of factor analysis, we developed the UPSA-Brief, which consists of 2 subscales (communication and financial) from the original UPSA. UPSA-Brief scores were correlated with cognitive functioning, symptoms of psychosis, age, and education. We further tested the sensitivity and specificity of the UPSA-Brief for predicting residential independence using receiver-operating characteristic (ROC) curves. Finally, sensitivity to change was assessed through comparison of 2 interventions for improving UPSA-Brief scores. UPSA-Brief scores were highly correlated with scores on the full version of the UPSA (r = .91), with overall cognitive functioning (r = .57), and with negative symptoms (r = -.32). The discriminant validity of the UPSA-Brief was adequate (ROC area under the curve [AUC] = 0.73; 95% confidence interval [CI]: 0.67-0.78), with greatest dichotomization for the UPSA-Brief at a cutoff score of 60. The UPSA-Brief was significantly better than the Dementia Rating Scale, Positive and Negative Syndromes Scale positive, and Positive and Negative Syndromes Scale negative at predicting residential independence (all P values < .05). Participants receiving a behavioral intervention also improved significantly compared with a support condition (P = .023). The UPSA-Brief has adequate psychometric properties, predicts residential independence, is sensitive to change, and requires only 10-15 minutes to administer. Therefore, the UPSA-Brief may be a useful performance-based functional outcome scale.
我们开发并测试了一个简短量表的有效性,该量表用于评估严重精神疾病患者的日常功能。对434名患有精神分裂症或分裂情感性障碍的成年人样本进行了加利福尼亚大学圣地亚哥分校基于表现的技能评估(UPSA),该评估在生活功能的5个领域(如财务和规划)评估功能技能。通过因子分析,我们开发了UPSA简表,它由原始UPSA的2个子量表(沟通和财务)组成。UPSA简表得分与认知功能、精神病症状、年龄和教育程度相关。我们进一步使用接受者操作特征(ROC)曲线测试了UPSA简表在预测居住独立性方面的敏感性和特异性。最后,通过比较两种改善UPSA简表得分的干预措施来评估对变化的敏感性。UPSA简表得分与UPSA完整版得分高度相关(r = 0.91),与整体认知功能(r = 0.57)以及阴性症状(r = -0.32)高度相关。UPSA简表的判别效度足够(曲线下面积[AUC] = 0.73;95%置信区间[CI]:0.67 - 0.78),UPSA简表在截止分数为60时二分法最佳。在预测居住独立性方面,UPSA简表显著优于痴呆评定量表、阳性和阴性症状量表阳性以及阳性和阴性症状量表阴性(所有P值 < 0.05)。与支持性条件相比,接受行为干预的参与者也有显著改善(P = 0.023)。UPSA简表具有足够的心理测量学特性,能预测居住独立性,对变化敏感,且只需10 - 15分钟即可完成施测。因此,UPSA简表可能是一个有用的基于表现的功能结局量表。