Yang Xinyue, Wang Chenguang, Su Guanfang
Department of Ophthalmology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin, China.
Int Ophthalmol. 2019 Apr;39(4):957-970. doi: 10.1007/s10792-019-01095-8. Epub 2019 Mar 20.
To review and summarize the recent progress in the diagnosis and treatment of Coats' disease.
Literature was collected from Web of Science, Medline and Pubmed, through searching of these keywords: "Coats' disease", "diagnosis" and "treatment".
Coats' disease is characterized by idiopathic leaky retinal vascular telangiectasia and microvascular abnormalities often accompanied by intraretinal or subretinal exudation and retinal detachment. Neovascular glaucoma and phthisis bulbi often occur in advanced cases. Coats' disease has significant diversity in terms of its clinical presentation and morphology. Anti-VEGF therapy combined with laser photocoagulation for early Coats' disease and anti-VEGF therapy combined with minimally invasive vitrectomy for advanced Coats' disease can achieve good efficacy.
Early diagnosis and timely treatment based on clinical stage are critical to retaining the patient's visual function. Patients should be aware that close long-term follow-up is necessary.
回顾并总结Coats病诊断与治疗的近期进展。
通过检索关键词“Coats病”“诊断”和“治疗”，从科学网、医学期刊数据库和PubMed收集文献。
Coats病的特征为特发性视网膜血管渗漏性毛细血管扩张和微血管异常，常伴有视网膜内或视网膜下渗出及视网膜脱离。晚期病例常出现新生血管性青光眼和眼球痨。Coats病在临床表现和形态学方面具有显著多样性。早期Coats病采用抗血管内皮生长因子（VEGF）治疗联合激光光凝，晚期Coats病采用抗VEGF治疗联合微创玻璃体切除术可取得良好疗效。
基于临床分期的早期诊断和及时治疗对于保留患者视功能至关重要。患者应知晓长期密切随访是必要的。
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