Válek Vlastimil, Kysela Petr, Kala Zdenek, Kiss Igor, Tomásek Jirí, Petera Jirí
Department of Radiology, FN Brno and LF MU Brno, Jihlavská 20, CZ-36900 Brno, Czech Republic.
Eur J Radiol. 2007 May;62(2):175-9. doi: 10.1016/j.ejrad.2007.01.037. Epub 2007 Mar 6.
To evaluate the effect of radiation therapy including intraluminal brachytherapy with iridium-192 on survival of patients with malignant biliary strictures (cholangiocarcinoma, histologically improved) treated with metallic stent in a prospective randomised study.
In the prospective randomised study, 21 patients with cholangiocarcinoma were treated with implantation of percutaneous stents followed with intraluminal Ir-192 brachytherapy (mean dose 30 Gy) and external radiotherapy (mean dose 50 Gy) and 21 patients were treated only with stents insertion. We did not find any statistically significant differences in age and tumor localization between these two groups of patients.
All the patients died. In the group of patients treated with brachytherapy and with stent implantation, the mean survival time was 387.9 days. In the group of patients treated only with stent insertion the mean survival was 298 days. In effort to eliminate possible effect of external radiotherapy we treated the control group of eight patients with cholangiocarcinoma by stent insertion and brachytherapy only.
Our results show that combined radiation therapy could extend the survival in the patients with cholangiocarcinoma obstruction.
在一项前瞻性随机研究中，评估包括使用铱 - 192腔内近距离放射治疗在内的放射治疗对接受金属支架治疗的恶性胆管狭窄（胆管癌，组织学改善）患者生存的影响。
在该前瞻性随机研究中，21例胆管癌患者接受经皮支架植入，随后进行腔内铱 - 192近距离放射治疗（平均剂量30 Gy）和外照射放疗（平均剂量50 Gy），21例患者仅接受支架植入。我们发现这两组患者在年龄和肿瘤定位方面没有任何统计学上的显著差异。
所有患者均死亡。在接受近距离放射治疗和支架植入的患者组中，平均生存时间为387.9天。在仅接受支架植入的患者组中，平均生存期为298天。为了消除外照射放疗可能的影响，我们仅对8例胆管癌患者组成的对照组进行了支架植入和近距离放射治疗。
我们的结果表明，联合放射治疗可延长胆管癌梗阻患者的生存期。
