Ozgönenel Bülent, Rajpurkar Madhvi, Lusher Jeanne M
Carman and Ann Adam's Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan 48201-2196, USA.
Postgrad Med J. 2007 Mar;83(977):159-63. doi: 10.1136/pgmj.2006.052118.
Desmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It has proved useful in treating or preventing bleeding episodes in patients with von Willebrand disease, haemophilia A and platelet function defects. Its efficacy in achieving a satisfactory level of haemostasis has reduced the use of blood products to treat bleeding episodes. Clinicians need to become familiar with the use of this drug that has become a home medication for many patients with inherited bleeding disorders.
去氨加压素是血管加压素的类似物，通过诱导血管性血友病因子从内皮细胞储存部位释放而发挥显著的止血作用。已证明它在治疗或预防血管性血友病、甲型血友病和血小板功能缺陷患者的出血发作方面有用。其在实现满意止血水平方面的疗效减少了用于治疗出血发作的血液制品的使用。临床医生需要熟悉这种已成为许多遗传性出血性疾病患者家庭用药的药物的使用。
