Ghosh Sujoy, Ghosh Arjun Kumar, Ghosh Sandip Kumar
Ayr Hospital, Dalmellington Road, Ayr, Ayrshire, UK.
Postgrad Med J. 2007 Mar;83(977):173-7. doi: 10.1136/pgmj.2006.051094.
Up to 40% of acute ischaemic strokes in young adults are cryptogenic in nature, that is, no cause is determined. In more than half of these patients, patent foramen ovale (PFO) is seen along with an increased incidence of atrial septal aneurysm. The commonest method of investigation is echocardiography (preferably transoesophageal echocardiography). On the basis of available evidence, low risk patients are treated with antiplatelet agents and high risk patients with warfarin. There are inconclusive data on the efficacy of PFO closure to prevent stroke recurrence. However, if there is recurrent stroke or intolerance to medical therapy, percutaneous closure is carried out.
在年轻成年人中，高达40%的急性缺血性中风本质上是隐源性的，也就是说，病因未明。在超过一半的这些患者中，可发现卵圆孔未闭（PFO），同时房间隔瘤的发生率也有所增加。最常用的检查方法是超声心动图（最好是经食管超声心动图）。根据现有证据，低风险患者用抗血小板药物治疗，高风险患者用华法林治疗。关于PFO封堵预防中风复发的疗效，数据尚无定论。然而，如果出现复发性中风或对药物治疗不耐受，则进行经皮封堵。
