Kwon Yong Chol, Yun Young Ho, Lee Ki Heon, Son Ki Young, Park Sang Min, Chang Yoon Jung, Wang Xin Shelley, Mendoza Tito R, Cleeland Charles S
Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea.
Oncology. 2006;71(1-2):69-76. doi: 10.1159/000100450. Epub 2007 Mar 5.
Symptoms other than their primary disease can interfere in the lives of terminal cancer patients. We sought to identify which of these symptoms is most important.
We administered a questionnaire, including the M.D. Anderson Symptom Inventory (MDASI), to 142 terminal cancer patients at the National Cancer Center, Korea. The validity of the MDASI was tested by principal-axis factor analysis and Cronbach's alpha coefficient. Stepwise multiple regression analysis was used to determine the symptoms that interfered most in terminal cancer patients' lives.
Factor analysis showed that it was composed of two factors (symptom and interference scales). Cronbach's alpha coefficients of symptom and interference scales were each >0.70. The patients had an average of 11 of 13 symptoms of the MDASI. Pain was the most common and severe, followed by feelings of distress and fatigue. Fatigue was the most highly correlated with interference sum. In stepwise multiple regression analysis, the most interfering symptom was fatigue.
Although pain was the most common and severe symptom, fatigue was the most important symptom interfering in the lives of terminal cancer patients. In treating terminal cancer patients, healthcare providers should actively intervene to reduce both fatigue and pain.
除原发性疾病的症状外，其他症状也会影响晚期癌症患者的生活。我们试图确定这些症状中哪一个最为重要。
我们向韩国国立癌症中心的142名晚期癌症患者发放了一份问卷，其中包括MD安德森症状问卷（MDASI）。通过主轴因子分析和克朗巴哈系数对MDASI的效度进行了检验。采用逐步多元回归分析来确定对晚期癌症患者生活影响最大的症状。
因子分析表明它由两个因子（症状和干扰量表）组成。症状量表和干扰量表的克朗巴哈系数均>0.70。患者平均有MDASI中13种症状中的11种。疼痛是最常见、最严重的症状，其次是苦恼感和疲劳感。疲劳与干扰总分的相关性最高。在逐步多元回归分析中，干扰最大的症状是疲劳。
虽然疼痛是最常见、最严重的症状，但疲劳是影响晚期癌症患者生活的最重要症状。在治疗晚期癌症患者时，医疗服务提供者应积极干预，以减轻疲劳和疼痛。
