Lacey J H, Crisp A H, Kalucy R S, Hartmann M K, Chien C N
Br Med J. 1975 Dec 6;4(5996):556-8. doi: 10.1136/bmj.4.5996.556.
The relation between reduced nutritional intake, with consequent weight loss, and sleep disturbance was studied by comparing certain sleep encephalogram patterns in a group of inpatients with anorexia nervosa before, during, and after a regimen of refeeding with a normal diet to a matched population mean weight. At low body weights patients had less sleep and more restlessness, especially in the last four hours of the night. During refeeding and weight gain slow-wave sleep initially increased and then tended to decrease during the final stage of restoration of weight back to matched population mean levels. With the overall weight gain, however, there was a significant increase in length of sleep and rapid eye movement sleep, the latter increasing especially during the later stages of weight gain. These results reaffirm that insomnia, and especially early morning waking, is associated with low body weight in anorexia nervosa, and their implications are discussed with particular reference to a hypothetical association between various anabolic profiles and the need for differing components of sleep.
通过比较一组神经性厌食症住院患者在采用正常饮食重新喂养至匹配人群平均体重的方案之前、期间和之后的某些睡眠脑电图模式，研究了营养摄入减少及随之而来的体重减轻与睡眠障碍之间的关系。在低体重时，患者睡眠较少且更加烦躁不安，尤其是在夜间的最后四个小时。在重新喂养和体重增加期间，慢波睡眠最初增加，然后在体重恢复到匹配人群平均水平的最后阶段趋于减少。然而，随着总体体重增加，睡眠时间和快速眼动睡眠显著增加，后者在体重增加的后期尤其增加。这些结果再次证实，失眠，尤其是早醒，与神经性厌食症患者的低体重有关，并特别参照各种合成代谢特征与不同睡眠成分需求之间的假设关联对其影响进行了讨论。
