Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tuebingen, D-7400 Tübingen, Federal Republic of Germany.
Planta Med. 1985 Dec;51(6):473-7. doi: 10.1055/s-2007-969566.
Ancient Hindu Ayurvedic texts described the use of extracts from COLEUS species. An isolated diterpene from COLEUS FORSKOHLII, called forskolin, was demonstrated to be a hypotensive agent with spasmolytic, cardiotonic and platelet aggregation inhibitory activity. It has been shown to be a powerful activator of the enzyme adenylate cyclase in various tissues. Forskolin is thought to act on the catalytic subunit and also on the coupling mechanism of guanine regulatory sites (Ns and Ni) with the catalytic subunit. It is now clear that forskolin elicits physiological responses which have been shown to be cAMP-dependent.
古印度的阿育吠陀文本描述了使用唇形科植物提取物。从唇形科植物forskolii 中分离出的一种二萜，称为 forskolin，被证明是一种具有降压、松弛平滑肌、强心和抑制血小板聚集活性的药物。它已被证明是各种组织中腺苷酸环化酶的强力激活剂。 forskolin 被认为作用于催化亚基，也作用于鸟嘌呤调节部位（Ns 和 Ni）与催化亚基的偶联机制。现在很清楚，forskolin 引起的生理反应已被证明是 cAMP 依赖性的。
