School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin 300350, P. R. China.
J Ind Microbiol Biotechnol. 2021 Apr 30;48(1-2). doi: 10.1093/jimb/kuab009.
Forskolin, a class of labdane-type diterpenoid, has significant medicinal value in anticancer, antiasthmatic, antihypertensive, and heart-strengthening treatments. The main source of natural forskolin is its extraction from the cork tissue of the root of Coleus forskohlii. However, conventional modes of extraction pose several challenges. In recent years, the construction of microbial cell factories to produce medicinal natural products via synthetic biological methods has effectively solved the current problems and is a research hotspot in this field. This review summarizes the recent progress in the heterologous synthesis of forskolin via synthetic biological technology, analyzes the current challenges, and proposes corresponding strategies.
福司可林是一种裂环烯醚萜类二萜化合物，在抗癌、抗哮喘、降血压和强心治疗方面具有重要的药用价值。天然福司可林的主要来源是从毛喉鞘蕊花的根的软木组织中提取。然而，传统的提取模式存在一些挑战。近年来，通过合成生物学方法构建微生物细胞工厂来生产药用天然产物，有效地解决了当前的问题，成为该领域的研究热点。本文综述了通过合成生物学技术异源合成福司可林的最新进展，分析了当前的挑战，并提出了相应的策略。
